TIMP1 down-regulation enhances gemcitabine sensitivity and reverses chemoresistance in pancreatic cancer

Tan, Y; Li, XN; Tian, ZF; Chen, SX; Zou, JM; Lian, GD; Chen, SJ; Huang, KH; Chen, YT

Huang, KH; Chen, YT (corresponding author), Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, Guangzhou 510120, Peoples R China.

BIOCHEMICAL PHARMACOLOGY, 2021; 189 ():

Abstract

The therapeutic effect of gemcitabine (GEM) in pancreatic ductal adenocarcinoma (PDAC) is limited due to low drug sensitivity and high drug resistance......

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