Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

Li, B; Clohisey, SM; Chia, BS; Wang, B; Cui, A; Eisenhaure, T; Schweitzer, LD; Hoover, P; Parkinson, NJ; Nachshon, A; Smith, N; Regan, T; Farr, D; Gutmann, MU; Bukhari, SI; Law, A; Sangesland, M; Gat-Viks, I; Digard, P; Vasudevan, S; Lingwood, D; Dockrell, DH; Doench, JG; Baillie, JK; Hacohen, N

Hacohen, N (corresponding author), Broad Inst MIT & Harvard, 415 Main St, Cambridge, MA 02142 USA.; Baillie, JK (corresponding author), Univ Edinburgh, Roslin Inst, Easter Bush EH25 9RG, Scotland.; Baillie, JK (corresponding author), Royal Infirm Edinburgh NHS Trust, Intens Care Unit, Edinburgh EH16 5SA, Midlothian, Scotland.; Hacohen, N (corresponding author), Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USA.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

Host dependency factors that are required for influenza A virus infection may serve as therapeutic targets as the virus is less likely to bypass them ......

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