Lysosome and Inflammatory Defects in GBA1-Mutant Astrocytes Are Normalized by LRRK2 Inhibition

Sanyal, A; DeAndrade, MP; Novis, HS; Lin, S; Chang, JJ; Lengacher, N; Tomlinson, JJ; Tansey, MG; LaVoie, MJ

LaVoie, MJ (corresponding author), Hale Bldg Transformat Med,Room 10016M, Boston, MA 02115 USA.

MOVEMENT DISORDERS, 2020; 35 (5): 760

Abstract

Background Autosomal recessive mutations in the glucocerebrosidase gene, Beta-glucocerebrosidase 1 (GBA1), cause the lysosomal storage disorder Gauche......

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