Structural basis for the biosynthesis of lovastatin

Wang, JL; Liang, JD; Chen, L; Zhang, W; Kong, LL; Peng, C; Su, C; Tang, Y; Deng, ZX; Wang, ZJ

Deng, ZX; Wang, ZJ (corresponding author), Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai, Peoples R China.; Deng, ZX; Wang, ZJ (corresponding author), Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai, Peoples R China.

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

Statins are effective cholesterol-lowering drugs. Lovastatin, one of the precursors of statins, is formed from dihydromonacolin L (DML), which is synt......

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