Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents

Huang, LL; Huang, JW; Nie, H; Li, YZ; Song, LX; Wu, FH

Huang, JW; Wu, FH (corresponding author), Shanghai Inst Technol, Sch Chem & Environm Engn, Dept Pharmaceut Engn, Shanghai, Peoples R China.; Huang, JW; Wu, FH (corresponding author), Shanghai Engn Res Ctr Green Fluoropharmaceut Tech, Shanghai, Peoples R China.; Huang, JW (corresponding author), Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai, Peoples R China.

RSC MEDICINAL CHEMISTRY, 2021; 12 (8): 1374

Abstract

A series of combretastatin A-4 (CA-4) sulfamate derivatives were synthesized and their structure-activity relationship on tubulin, arylsulfatase and t......

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