The transcription factor Zfp281 sustains CD4(+) T lymphocyte activation through directly repressing Ctla-4 transcription

Guo, J; Xue, ZH; Ma, RY; Yi, WW; Hui, ZY; Guo, YX; Yao, YX; Cao, WQ; Wang, JL; Ju, ZY; Lu, LR; Wang, L

CELLULAR & MOLECULAR IMMUNOLOGY, 2020; 17 (12): 1222

Abstract

The expression of coinhibitory receptors, such as CTLA-4, on effector T cells is a key mechanism for the negative regulation of T-cell activation. How......

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