STIM1 knock-down decreases the affinity of obinutuzumab for CD20 by altering CD20 localization to Triton-soluble membrane

Heo, W; Jin, N; Park, MS; Kim, HY; Yoon, SM; Lee, J; Kim, JY

Kim, JY (corresponding author), Yonsei Univ, Dept Pharmacol & Brain, Coll Med, Korea 21 Project Med Sci, Seoul 03722, South Korea.; Lee, J (corresponding author), Yonsei Univ, Coll Pharm, Yonsei Inst Pharmaceut Sci, Incheon 21983, South Korea.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2020; 200 (3): 260

Abstract

Obinutuzumab is thought to exert its effects through its high antibody-dependent cellular cytotoxicity (ADCC) via glyco-engineering of the Fc region. ......

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