CSP-1103 (CHF5074) stabilizes human transthyretin in healthy human subjects

Qiang, LX; Guan, YX; Li, XS; Liu, L; Mu, YS; Sugano, A; Takaoka, Y; Sakaeda, T; Imbimbo, BP; Yamamura, KI; Jin, SD; Li, ZH

Jin, SD (reprint author), Harbin Med Univ, Div Resp Dis, Affiliated Hosp 4, Harbin 150001, Heilongjiang, Peoples R China.; Li, ZH (reprint author), Harbin Med Univ, Dept Histol & Embryol, Harbin 150081, Heilongjiang, Peoples R China.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 2017; 24 (1): 42

Abstract

Hereditary amyloid polyneuropathy is a type of protein misfolding disease. Transthyretin (TTR) is a homotetrameric serum protein and TTR tetramer diss......

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