The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure

Martin, PR; Couve, S; Zutterling, C; Albelazi, MS; Groisman, R; Matkarimov, BT; Parsons, JL; Elder, RH; Saparbaev, MK

Elder, RH (reprint author), Univ Salford, Biomed Res Ctr, Cockcroft Bldg, Salford M5 4NT, Lancs, England.; Saparbaev, MK (reprint author), Univ Paris Sud, Equipe Labellisee Ligue Natl Contre Canc, Grp Reparat ADN, CNRS UMR8200, Gustave Roussy Canc Campus,

SCIENTIFIC REPORTS, 2017; 7 ( ):

Abstract

Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previous......

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