Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

Qiao, WH; Chen, YX; Zhong, J; Madden, BJ; Charlesworth, CM; Martens, YA; Liu, CC; Knight, J; Ikezu, TC; Aishe, K; Zhu, YY; Meneses, A; Rosenberg, CL; Kuchenbecker, LA; Vanmaele, LK; Li, FY; Chen, K; Shue, F; Dacquel, MV; Fryer, J; Pandey, A; Zhao, N; Bu, GJ

Zhao, N; Bu, GJ (通讯作者)，Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA.;Zhao, N; Bu, GJ (通讯作者)，SciNeuro Pharmaceut, Rockville, MD 20805 USA.

MOLECULAR NEURODEGENERATION, 2023; 18 (1):

Abstract

Background The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer's disease (AD) risk. T......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索