TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

Moutinho, M; Coronel, I; Tsai, AP; Di Prisco, GV; Pennington, T; Atwood, BK; Puntambekar, SS; Smith, DC; Martinez, P; Han, S; Lee, Y; Lasagna-Reeves, CA; Lamb, BT; Bissel, SJ; Nho, K; Landreth, GE

Landreth, GE (通讯作者)，Indiana Univ Sch Med, Stark Neurosci Res Inst, Indianapolis, IN 46202 USA.;Landreth, GE (通讯作者)，Indiana Univ Sch Med, Dept Anat Cell Biol & Physiol, Indianapolis, IN 46202 USA.

GENOME MEDICINE, 2023; 15 (1):

Abstract

BackgroundTREM2 is a transmembrane receptor expressed by myeloid cells and acts to regulate their immune response. TREM2 governs the response of micro......

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