Active site competition is the mechanism for the inhibition of lipoprotein-associated phospholipase A(2) by detergent micelles or lipoproteins and for the efficacy reduction of darapladib

Zhuo, SQ; Yuan, C

Zhuo, SQ (corresponding author), Diazyme Labs Inc, 12889 Gregg Ct, Poway, CA 92064 USA.; Zhuo, SQ (corresponding author), Bayer HealthCare, 800 Dwight Way, Berkeley, CA 94710 USA.

SCIENTIFIC REPORTS, 2020; 10 (1):

Abstract

Lipoprotein associated phospholipase A(2) (Lp-PLA(2)) has been characterized for its interfacial activation as well as inhibition by detergent micelle......

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