Synthesis of Adagrasib (MRTX849), a Covalent KRASG12C Inhibitor Drug for the Treatment of Cancer

Chen, CY; Lu, ZC; Scattolin, T; Chen, CS; Gan, YH; McLaughlin, M

Chen, CY; Lu, ZC (通讯作者)，Mirati Therapeut, Chem Proc R&D, San Diego, CA 92121 USA.

ORGANIC LETTERS, 2023; ():

Abstract

A concise, transition-metal and protection-free synthesis of adagrasib (MRTX849), a novel KRASG12C inhibitor drug recently approved by the FDA, is rep......

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