A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators

Chang, YC; Lee, HL; Yang, WJ; Hsieh, ML; Liu, CC; Lee, TY; Huang, JY; Nong, JY; Li, FA; Chuang, HL; Ding, ZZ; Su, WL; Chueh, LY; Tsai, YT; Chen, CH; Mochly-Rosen, D; Chuang, LM

Chuang, LM (通讯作者)，Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.;Mochly-Rosen, D (通讯作者)，Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA.;Chuang, LM (通讯作者)，Natl Taiwan Univ, Grad Inst Mol Med, Taipei, Taiwan.;Chuang, LM (通讯作者)，Natl Taiwan Univ, Grad Inst Clin Med, Taipei, Taiwan.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of ac......

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