Biocatalytic synthesis of planar chiral macrocycles

Gagnon, C; Godin, E; Minozzi, C; Sosoe, J; Pochet, C; Collins, SK

Collins, SK (corresponding author), Univ Montreal, Ctr Green Chem & Catalysis, Dept Chim, CP 6128 Stn Downtown, Montreal, PQ H3C 3J7, Canada.

SCIENCE, 2020; 367 (6480): 917

Abstract

Macrocycles can restrict the rotation of substituents through steric repulsions, locking in conformations that provide or enhance the activities of ph......

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