Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia

Chung, W; Kelly, AD; Kropf, P; Fung, H; Jelinek, J; Su, XY; Roboz, GJ; Kantarjian, HM; Azab, M; Issa, JPJ

Chung, W (reprint author), Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19122 USA.; Chung, W (reprint author), Coriell Inst Med Res, 403 Haddon Ave, Camden, NJ 08103 USA.

CLINICAL EPIGENETICS, 2019; 11 ():

Abstract

BackgroundGuadecitabine is a novel DNA methyltransferase (DNMT) inhibitor with improved pharmacokinetics and clinical activity in a subset of patients......

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