An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

Nagy, Z; Seneviratne, JA; Kanikevich, M; Chang, W; Mayoh, C; Venkat, P; Du, YH; Jiang, CZ; Salib, A; Koach, J; Carter, DR; Mittra, R; Liu, T; Parker, MW; Cheung, BB; Marshall, GM

Cheung, BB; Marshall, GM (corresponding author), UNSW, Childrens Canc Inst Australia Med Res, Lowy Canc Res Ctr, Sydney, NSW, Australia.; Cheung, BB; Marshall, GM (corresponding author), UNSW Sydney, Sch Womens & Childrens Hlth, Randwick, NSW, Australia.; Cheung, BB (corresponding author), Tongji Univ, Sch Life Sci & Technol, Shanghai, Peoples R China.; Marshall, GM (corresponding author), Sydney Childrens Hosp, Kids Canc Ctr, Randwick, NSW, Australia.

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

To achieve the very high oncoprotein levels required to drive the malignant state cancer cells utilise the ubiquitin proteasome system to upregulate t......

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