Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome

Khoury, ES; Sharma, A; Ramireddy, RR; Thomas, AG; Alt, J; Fowler, A; Rais, R; Tsukamoto, T; Blue, ME; Slusher, B; Kannan, S; Kannan, RM

Kannan, RM (corresponding author), Wilmer Eye Inst, Ctr Nanomed, Ophthalmol, 400 North Broadway, Baltimore, MD 21231 USA.; Kannan, S (corresponding author), Dept Anesthesiol & Crit Care Med, Charlotte Bloomberg Childrens Ctr 6318D, Baltimore, MD 21287 USA.

THERANOSTICS, 2020; 10 (13): 5736

Abstract

Background: Elevated glutamate production and release from glial cells is a common feature of many CNS disorders. Inhibitors of glutaminase (GLS), the......

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