Preclinical pharmacokinetics, disposition, and translational pharmacokinetic/pharmacodynamic modeling of savolitinib, a novel selective cMet inhibitor

Gu, Y; Sai, Y; Wang, J; Yu, MJ; Wang, GL; Zhang, L; Ren, HC; Fan, SM; Ren, YX; Qing, WG; Su, WG

Sai, Y; Wang, J (reprint author), Hutchison MediPharma Ltd, Dept DMPK & Clin Pharmacol, Bldg 4,720 Cailun Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019; 136 ():

Abstract

Savolitinib is a novel small-molecule selective cMet inhibitor. This work characterized its pharmacokinetics in preclinical phase, established the pre......

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