Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer

Johmura, Y; Maeda, I; Suzuki, N; Wu, WW; Goda, A; Morita, M; Yamaguchi, K; Yamamoto, M; Nagasawa, S; Kojima, Y; Tsugawa, K; Inoue, N; Miyoshi, Y; Osako, T; Akiyama, F; Maruyama, R; Inoue, J; Furukawa, Y; Ohta, T; Nakanishi, M

Nakanishi, M (reprint author), Univ Tokyo, Inst Med Sci, Div Canc Cell Biol, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan.; Ohta, T (reprint author), St Marianna Univ, Grad Sch Med, Dept Translat Oncol, Miyamae Ku, 2-16-1 Sugao, Kawasaki, Kanagawa

JOURNAL OF CLINICAL INVESTIGATION, 2018; 128 (12): 5603

Abstract

The agonistic/antagonistic biocharacter of selective estrogen receptor modulators (SERMs) can have therapeutic advantages, particularly in the case of......

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