Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction

Liu, CS; Yang-Yen, HF; Suen, CS; Hwang, MJ; Yen, JJY

Yen, JJY (reprint author), Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan.; Yen, JJY (reprint author), Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.

SCIENTIFIC REPORTS, 2017; 7 ( ):

Abstract

JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full activatio......

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