MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment

Fang, DD; Tang, QQ; Kong, YH; Wang, QX; Gu, JX; Fang, X; Zou, P; Rong, T; Wang, JW; Yang, DJ; Zhai, YF

Yang, DJ; Zhai, YF (reprint author), Ascentage Pharma Suzhou Co Ltd, 218 Xinghu St, Suzhou, Jiangsu, Peoples R China.; Yang, DJ (reprint author), Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Expt Res, State Key Lab Oncol South China,Canc Ctr, G

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019; 7 (1):

Abstract

Background Programmed death-1 (PD-1) immune checkpoint blockade has achieved clinical successes in cancer therapy. However, the response rate of anti-......

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