Diabetes Care:糖尿病患者控制心血管疾病危险因素可大大降低心血管疾病风险

2016-05-20 崔倩 译 MedSci原创

在糖尿病(DM)患者中控制心血管疾病(CVD)的危险因素可减少CVD事件的数量,但多因素的风险因子控制的效果还不能很好地被量化。研究人员通过检测是否同时靶向血压(BP),低密度脂蛋白胆固醇(LDL-C)和糖化血红蛋白(HbA1c)治疗就可以降低美国成人糖尿病CVD事件的风险。来自美国的研究人员研究了2,018名28-86岁的成人糖尿病患者,这些参与者没有已知的CVD疾病,他们来自于社区动脉粥样硬化

糖尿病(DM)患者中控制心血管疾病(CVD)的危险因素可减少CVD事件的数量,但多因素的风险因子控制的效果还不能很好地被量化。研究人员通过检测是否同时靶向血压(BP),低密度脂蛋白胆固醇(LDL-C)和糖化血红蛋白(HbA1c)治疗就可以降低美国成人糖尿病CVD事件的风险。

来自美国的研究人员研究了2,018名28-86岁的成人糖尿病患者,这些参与者没有已知的CVD疾病,他们来自于社区动脉粥样硬化风险(ARIC)研究,动脉粥样硬化多民族研究(MESA),和Jackson心脏研究(JHS)。Cox回归用来检验在平均11年的随访过程中,通过控制这些人群的BP,LDL-C和HbA1c的目标水平,这些人群的冠状动脉心脏疾病(CHD)和CVD事件。

该研究共包括2018例DM患者(43%为男性,55%为非裔美国人),分别有41.8%,32.1%和41.9%的人控制BP,LDL-C和HbA1c目标水平;分别有41.1%,26.5%,和7.2%的人达到目标水平中的一个,两个,或所有三个因素。处于BP,LDL-C,或HbA1c的目标水平分别降低CVD事件17%,33%,和37%的风险,分别降低CHD事件17%,41%,和36%的风险(除了BP对于CHD的风险,P<0.05到P<0.0001);这些达到一个,两个,或所有三个危险因素目标水平(vs 无)的受试者分别逐渐降低CVD事件36%,52%,62%的调整后风险,分别降低CHD事件41%,56%和60%的调整后风险(P<0.001至P<0.0001)。倾向分数调整显示出类似的结果。

DM患者同时达到BP、LDL-C和HbA1c的最佳控制水平是非常罕见的,但这可以大大降低CHD和CVD风险。

原始出处:

Nathan D. Wong,Yanglu Zhao,Rohini Patel,et al.Cardiovascular Risk Factor Targets and Cardiovascular Disease Event Risk in Diabetes,Diabetes Care,2016.5.20

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