NEJM:收缩压和舒张压对心血管结局的影响

2019-07-18 xing.T MedSci原创

虽然收缩压升高对预后有较大影响,但无论高血压的定义如何(≥140/90 mmHg或≥130/80 mmHg),收缩期高血压和舒张期高血压均会独立影响不良心血管事件的风险。

门诊收缩压和舒张压与心血管结局之间的关系仍不明确,最近修订的指南有两个不同的阈值(≥140/90 mmHg和≥130/80 mmHg)用于高血压治疗。 

近日,顶级医学期刊NEJM上发表了一篇研究文章,研究人员利用一般门诊人群中130万成人的数据,进行了多变量Cox生存分析,以确定收缩压和舒张压高血压心肌梗死、缺血性卒中或出血性卒中复合结局的影响。该分析控制了人口统计特征和共存疾病。

收缩压和舒张压的负担可各自独立预测不良结局。在生存模型中,收缩期高血压(≥140mmHg; z分数每单位增加的风险比为1.18; 95%置信区间[CI]为1.17-1.18)和舒张期高血压(≥90mmHg;每单位z分数增加的风险比为1.06; 95%CI为1.06-1.07)持续负担独立预测复合结局。在较低高血压阈值(≥130/80 mmHg)和以收缩压和舒张压作为没有高血压阈值的预测因子时可观察到类似的结果。可以看出舒张压与结局之间的J曲线关系至少部分可通过年龄和其他协变量以及舒张压最低四分位数人群中收缩期高血压较大影响来解释。

虽然收缩压升高对预后有较大影响,但无论高血压的定义如何(≥140/90 mmHg或≥130/80 mmHg),收缩期高血压和舒张期高血压均会独立影响不良心血管事件的风险。 

原始出处:

Alexander C. Flint,et al.Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes.NEJM.2019.https://www.nejm.org/doi/full/10.1056/NEJMoa1803180

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    2019-07-19 百草

    666

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    2019-07-18 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2019-07-18 184****9840

    学习了,谢谢分享。

    0

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