Neurology:蛛网膜下腔出血后脑血管痉挛的血管内治疗

2019-07-06 xing.T MedSci原创

由此可见,一种利用频繁和早期EVT的预防策略可以降低SAH患者DCI风险并改善其功能结局。研究人员建议对SAH患者接受预防性EVT策略的价值进行前瞻性评估。

延迟性脑缺血(DCI)与蛛网膜下腔出血(SAH)后的不良预后密切相关。脑血管痉挛是DCI的主要原因,需要特别注意。近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员对2项观察性SAH队列进行了合并分析,旨在评估血管痉挛治疗对SAH结局的效果。

研究人员汇总了2005年至2012年期间2个机构连续就诊的SAH患者数据,并在6个月的随访中分析了保守和血管内血管治疗(EVT)对DCI发生率和不良结局(改良Rankin量表评分>2)的影响。

最终分析纳入了1057名SAH患者,在人口统计学指标(年龄和性别)、临床特征(Hunt和Hess分级、急性脑积水、治疗方式和感染)和影像学特征(Fisher等级和动脉瘤位置)方面没有差异。然而,EVT发生率(24.4%[121/495] vs. 14.4%[81/562],p<0.0001)和时间(SAH后第6天 vs. 第8.9天首次治疗,p<0.0001)有显著差异。DCI的发生率(20.8% vs. 29%,p=0.0001)和不良结局(44% vs. 50.6%,p=0.04)在更频繁且EVT更早的队列中发生率较低。多变量分析证实了EVT标准对DCI风险和结局的独立影响。

由此可见,一种利用频繁和早期EVT的预防策略可以降低SAH患者DCI风险并改善其功能结局。研究人员建议对SAH患者接受预防性EVT策略的价值进行前瞻性评估。

原始出处:

Ramazan Jabbarli, et al.Endovascular treatment of cerebral vasospasm after subarachnoid hemorrhage More is more.Neurology.2019.https://doi.org/10.1212/WNL.0000000000007862

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    2019-08-01 yinhl1978
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    2019-07-08 apoenzyme
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