J Rheumatol:膝关节骨关节炎中渗出滑膜炎与关节结构变化的关系

2017-09-11 xiangting MedSci原创

膝关节软骨和软骨下骨异常预测渗出滑膜炎的变化,但渗出滑膜炎并不能预测膝关节结构的变化。

这项研究旨在描述24个月内膝关节骨关节炎(OA)患者渗出滑膜炎与关节结构异常之间的关联。

对413例症状性OA患者的随机对照试验数据进行析因分析(年龄63±7岁,女性208例)。使用磁共振成像评估膝关节渗出滑膜炎体积和评分,软骨缺损,软骨体积和骨髓损伤(BML)。使用影像学评估关节腔狭窄(JSN)和骨赘。使用最不显著变化标准来定义渗出滑膜炎容积的变化。膝关节症状由Western Ontario and McMaste大学OA指数评估。纵向分析使用多变量线性/ logistic回归和多层次广义混合效应模型。

总渗出滑膜炎容积从基线(8.0±8.5 ml)到随访(9.0±10.5 ml)均适度增加。基线BML,软骨缺损,JSN和骨赘评分与渗出滑膜炎容积变化呈正相关(p <0.05)。基线软骨缺损和JSN也与渗出滑膜炎评分变化相关(p <0.05)。然而,除了软骨体积之外,基线渗出滑膜炎评分和体积一致均不能预测上述结构中的改变。在混合效应模型中,膝盖渗出滑膜炎与BML呈正相关(体积:β= 1.19ml /等级;评分:OR = 1.75 /等级)和软骨缺损(体积:β= 1.87ml /等级;评分:OR = 2.22 / 等级),而与软骨体积损失呈负相关。渗出滑膜炎体积变化与膝关节疼痛和僵硬评分的变化呈正相关(p <0.05)。

膝关节软骨和软骨下骨异常预测渗出滑膜炎的变化,但渗出滑膜炎并不能预测膝关节结构的变化。这些研究结果表明,滑膜炎症可能是OA关节结构异常的结果。

原始出处:
Xia Wang, Xingzhong Jin, Leigh Blizzard, et al. Associations Between Knee Effusion-synovitis and Joint Structural Changes in Patients with Knee Osteoarthritis. J Rheumatol. 01 September 2017. 

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    2018-06-28 lisa438
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    2017-09-13 lmm397
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