JAMA Intern Med:静脉血栓形成诊治十大要点:有危险因素者建议抗凝3个月

2017-06-09 钟巧青 高磊 中国循环杂志

JAMA内科医学杂志发文,提出应对有诱发因素的VTE患者检测其血栓形成倾向,以下是该文的十大要点。

JAMA内科医学杂志发文,提出应对有诱发因素的VTE患者检测其血栓形成倾向,以下是该文的十大要点。

1 在美国,每年有约30~60万患者受静脉血栓形成(VTE)这一疾病的影响。

2 VTE复发风险的评估最好是基于初发VTE是否有诱发因素,而不是遗传性血栓形成倾向的测试结果。

3 大多数发生VTE的患者都有近期手术史、制动、外伤、或患癌症,或同期使用激素类药物等,这些都被认为是VTE的诱发因素。

4  对于首次发生VTE且有诱发因素的患者,指南推荐应用仅3个月的抗凝药物。延长使用抗凝药物可能会增加出血的风险,且这样的出血风险更甚于再发VTE。

5 无明显上述诱发因素的VTE则需要更长时间的抗凝,因为这类患者再发VTE的风险高于延长抗凝药物导致的出血风险。

6 在急性血栓形成或正应用抗凝药物的过程中做血栓形成倾向检测常常会得出一些不确切的结果,如假阳性等。例如,天然的抗凝成分如蛋白质C/S和抗凝血酶在急性血栓性事件时常常被大量消耗,而且这些物质的水平在抗凝治疗时也是降低的。

7 最近的一项研究表明,有55%的患者在发生有诱发因素的VTE时接受了不恰当的血栓形成倾向检测。

8 对初次发生不明原因VTE的年轻(<45岁)患者,或VTE发生在临床罕见的部位时,则做该项测试可能有益。

9 对于无诱因VTE的年轻患者,或在罕见部位发生VTE,或动脉栓塞,或妊娠肥胖,则检测抗磷脂抗体、JAK2基因突变以及阵发性夜间血红蛋白尿,可能是有益的。

10 在VTE患者中应用CT等手段进行癌症筛查并无意义,仅推荐常规的、适龄的癌症筛查。

原始出处:

Arjun Gupta, Ravi Sarode, Srikanth Nagalla. Thrombophilia Testing in Provoked Venous Thromboembolism: A Teachable Moment. JAMA Intern Med. Published online June 5, 2017. doi:10.1001/jamainternmed.2017.1815

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    2018-05-09 fusion
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    2017-09-20 xue8602
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