J Thromb Haemost:身高越高越容易发生静脉血栓栓塞吗?

2017-05-30 xing.T MedSci原创

由此可见,身高越高,欧洲血统的成年人患VTE的风险就越高。这种相关性可能的解释,包括更高的人可能有更大的静脉表面积,更多的静脉瓣膜,或更大的静水压力,但仍需要进一步探讨。

身高较高与静脉血栓栓塞(VTE)的发生风险更大相关。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员旨在使用工具变量(IV)技术(孟德尔随机化)以进一步探讨这种相关性。研究人员将来自于社区动脉粥样硬化风险研究(ARIC研究)和心血管健康研究(CHS研究)两个队列研究以及梅奥诊所VTE研究(Mayo研究)一个病例对照研究中具有欧洲血统的参加者纳入研究分析。研究人员创建了两个针对身高的加权遗传风险评分(GRS);完整的GRS包含了来自于先前发表的荟萃分析中的668个单核苷酸多态性(SNPs),而限制性GRS包含了与体重无关与身高独立相关的362 个SNPs子集。研究人员采用标准的logistic回归模型和IV模型来估计身高每增加10cmVTE的比值比(OR),并采用反向方差加权随机效应荟萃分析合并了三个研究的ORs。9143名ARIC研究参与者和3180名CHS研究参在研究之初无VTE,其分别有367例和109例静脉血栓栓塞事件的发生。Mayo研究纳入了1143例VTE病例和1292例对照者。从非IV模型、

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    2017-06-29 xue8602
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    2018-03-07 fusion
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    2017-09-07 changfy
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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Wed May 31 06:18:35 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204625, encodeId=8ccb2046252b, content=学习了。。。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Wed May 31 06:11:19 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204612, encodeId=b76e204612db, content=亚洲血统的呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204521, encodeId=37b5204521f6, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Tue May 30 23:06:32 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-31 半夏微凉

    阅读了谢谢分享

    0

  5. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204521, encodeId=37b5204521f6, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Tue May 30 23:06:32 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-31 135****7952平儿

    学习了。。。。。。。。。。

    0

  6. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204521, encodeId=37b5204521f6, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Tue May 30 23:06:32 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-31 lou.minghong

    亚洲血统的呢?

    0

  7. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204521, encodeId=37b5204521f6, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Tue May 30 23:06:32 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-31 tanxingdoctor

    学习啦谢谢分享

    0

  8. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204521, encodeId=37b5204521f6, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Tue May 30 23:06:32 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-31 飛歌

    学习了很有用

    0

  9. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204521, encodeId=37b5204521f6, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Tue May 30 23:06:32 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-30 solarjin

    感谢梅斯医学,受教了

    0

  10. 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encodeId=dec720454ee2, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed May 31 00:09:02 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204529, encodeId=64b520452948, content=感谢梅斯医学,受教了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhbPwBo0yCebU4qpdSwzpBA1WFXMEUicoTnJDickpj9Ve1cUdNjjTiaDXmpXL47LYh3DdYkPOA2kddyZ/0, createdBy=508c2054450, createdName=solarjin, createdTime=Tue May 30 23:08:37 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204521, encodeId=37b5204521f6, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Tue May 30 23:06:32 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-30 laymankey

    感谢分享一下!

    0

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