Am J Med Sci:慢性完全闭塞性经皮冠状动脉介入治疗老年患者的临床疗效

2018-07-10 MedSci MedSci原创

目前尚未有研究探究冠状动脉慢性完全闭塞(CTO)经皮冠状动脉介入治疗(PCI)对老年CTO患者预后的影响。近日,安贞医院的一项研究对此进行了探究。研究纳入了2011年1月至2013年12月期间的445名CTO-PCI患者,根据年龄分为老年组(≥75岁,n=120,27.0%)和非老年组(<75岁,n=325,73.0%),随访3年,观察两组患者的术中与长期预后情况。主要研究终点为3年随访时心绞痛住

目前尚未有研究探究冠状动脉慢性完全闭塞(CTO)经皮冠状动脉介入治疗(PCI)对老年CTO患者预后的影响。近日,安贞医院的一项研究对此进行了探究。

研究纳入了2011年1月至2013年12月期间的445名CTO-PCI患者,根据年龄分为老年组(≥75岁,n=120,27.0%)和非老年组(<75岁,n=325,73.0%),随访3年,观察两组患者的术中与长期预后情况。主要研究终点为3年随访时心绞痛住院、再梗塞、心力衰竭或重复血运重建和心源性死亡的复合结局。

结果显示,与非老年组患者相比,老年组患者LM病变率(25.0 vs. 15.1%,P=0.015)、3支病变率(96.4% vs. 73.8%,P<0.001)、J-CTO分≥2(36.7% vs. 23.7%,P=0.006),以及syntax积分(27.0 vs. 26.0,P=0.006)明显更高,然而两组患者的手术成功率无明显差异(69.7% vs. 82.7%, P=0.097)。3年的心源性死亡率方面,老年组明显高于非老年组(15.0% vs. 4.6%, P<0.011)。此外,老年组患者在CTO开通组与CTO未开通组3年的心源性死亡率相当(15.0% vs. 16.0%,P=1.000)。主要终点发生率无明显差异(25.0% vs. 33.0%,P=0.486)。多因素分析显示,右冠CTO、左主干病变和3支病变是老年组患者3年心源性死亡率的独立预测因子。

综上所述,该研究结果表明,老年CTOs患者冠状动脉病变严重,预后不良。CTO PCI似乎没有明显改善老年CTOs患者的长期临床结果。右冠状动脉CTO和LM疾病联合3支血管病变可能是老年CTO患者3年心脏病死亡率的独立预测因素。

原始出处:

Zhang HP, Ai H, et al., Effect of Chronic Total Occlusion Percutaneous Coronary Intervention on Clinical Outcomes in Elderly Patients. Am J Med Sci. 2018 Feb;355(2):174-182. doi: 10.1016/j.amjms.2017.09.007. Epub 2017 Sep 20.

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    2018-07-10 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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