J Periodontal Res:肥胖是否可影响患者对牙周基础治疗的反应?

2015-12-17 MedSci MedSci原创

本研究旨在检测肥胖对牙周治疗后伤口愈合的影响,通过检测血脂、C反应蛋白(CRP)以及血清和龈沟液中细胞因子。

本研究旨在检测肥胖对牙周治疗后伤口愈合的影响,通过检测血脂、C反应蛋白(CRP)以及血清和龈沟液中细胞因子。

研究共纳入了30名牙周炎患者:15名肥胖(CPO)患者以及15名不肥胖的牙周炎患者。此外,研究还纳入了15名健康对照者。术前及基础治疗后3个月评估所有研究对象的血清高密度脂蛋白、低密度脂蛋白、甘油三酯、CRP水平、脂联素的水平、白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α以及IL-10水平,同时还需要测量所有患者的牙周临床指数。

结果发现,伴或不伴肥胖的牙周炎组患者在接受牙周基础治疗其牙周各项指标得到明显地改善(P<0.05),但是在临床附着水平获得上治疗前后并明显差异(P>0.05),此外,治疗后患者牙周袋探诊深度≥4 mm的位点有所减少。两组患者治疗后的高密度脂蛋白水平均明显增加(p > 0.05)。CRP水平的下降仅发生在正常体重组。基础治疗后,两组患者龈沟液中的IL-6、IL-10及TNF-α水平得到明显改善(P<0.05)。CPO患者仅有TNF-α的水平明显降低,而非肥胖牙周炎患者的TNF-α、IL-10以及脂联素的水平均显著降低。

总而言之,CPO患者对牙周治疗的反应同非肥胖牙周炎患者一样。这种相似的反应同患者龈沟液中脂联素的水平变化一致。但是,肥胖可影响牙周基础治疗后患者体内的CRP及血清脂肪细胞因子的水平。

原始出处:

Duzagac E, Cifcibasi E et al.. Is obesity associated with healing after non-surgical periodontal therapy? A local vs. systemic evaluation.J Periodontal Res. 2015 Dec 15. doi: 10.1111/jre.12340. 


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    2016-09-21 feather89
  2. [GetPortalCommentsPageByObjectIdResponse(id=1725967, encodeId=32a31e25967f4, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Sep 21 13:11:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56031, encodeId=b1f856031df, content=胖了容易得病, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=989f1678108, createdName=傻妮, createdTime=Mon Jan 11 22:35:00 CST 2016, time=2016-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47073, encodeId=65ae4e07380, content=一胖毁所有!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Dec 22 17:03:00 CST 2015, time=2015-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450439, encodeId=0f3f14504397f, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sat Dec 19 11:11:00 CST 2015, time=2015-12-19, status=1, ipAttribution=)]
    2016-01-11 傻妮

    胖了容易得病

    0

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    2015-12-22 xiaotaiyang1

    一胖毁所有!

    0

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