JAMA:低强度步行vs高强度步行锻炼对下肢外周动脉疾病步行能力的影响

2021-04-07 MedSci原创 MedSci原创

指南建议下肢外周动脉疾病(PAD)患者进行高强度地行走锻炼以改善步行能力,但高强度运动会导致PAD患者出现腿部缺血性症状,降低运动依从性。有证据表明,高强度行走运动导致的下肢缺血也可能会损伤小腿骨骼肌

指南建议下肢外周动脉疾病(PAD)患者进行高强度地行走锻炼以改善步行能力,但高强度运动会导致PAD患者出现腿部缺血性症状,降低运动依从性。有证据表明,高强度行走运动导致的下肢缺血也可能会损伤小腿骨骼肌。以舒适速度进行的低强度步行,不会引起腿部缺血性症状,提高PAD患者的运动依从性,但低强度的步行对PAD患者步行能力的影响尚不清楚。

近日研究人员比较了低强度步行、高强度步行以及不运动对PAD患者步行能力的影响

305名PAD患者随机分为低强度步行运动组(n=116)、高强度步行运动组(n=124)和非运动对照组(n=65),为期12个月。运动组在无监督的环境下每周步行锻炼5次,每次最多50分钟,佩戴计步设备记录运动强度和时间。低强度组参与者被要求控制步行速度,以不出现腿部缺血症状为限度。高强度组的步行速度可出现中度至重度腿部缺血症状,而非运动对照组接受为期12个月的每周电话教育指导。研究的主要终点为12个月时6分钟步行距离的平均变化。

参与者平均年龄69.3岁,女性占47.9%,黑人占59.3%,250名参与者(82%)完成了12个月随访。低强度运动组的6分钟步行距离从基线时的332.1米降低至12个月随访时的327.5米(组内平均变化为-6.4米),高强度运动组从338.1米增加至371.2米(组内平均变化为34.5米),运动组间的平均变化为-40.9米。非运动对照组6分钟步行距离从基线时的328.1米降低至12个月随访时的317.5米(组内平均变化为-15.1米),变化程度与低强度运动组相当(组间平均变化为8.7米)。总计出现184例严重不良事件,其中低强度组、高强度组和非运动对照组的不良事件发生率分别为0.64、0.65和0.46。

低强度 vs 高强度vs 对照组基线及12个月6min步行距离

研究认为,下肢外周动脉疾病患者,低强度家庭锻炼对患者步行能力无改善作用

原始出处

Mary M. McDermott et al.Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease The LITE Randomized Clinical Trial .JAMA. April 6, 2021.

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    2021-08-17 yuanming15
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    2021-08-02 月儿005

    不错学习了

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1654844, encodeId=5b961654844ff, content=<a href='/topic/show?id=4eb6632899b' target=_blank style='color:#2F92EE;'>#步行#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63289, encryptionId=4eb6632899b, topicName=步行)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5524567114, createdName=yuanming15, createdTime=Tue Aug 17 00:32:44 CST 2021, time=2021-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058132, encodeId=d6bc205813236, content=<a href='/topic/show?id=d104201831a' target=_blank style='color:#2F92EE;'>#下肢外周动脉疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20183, encryptionId=d104201831a, topicName=下肢外周动脉疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Fri Dec 10 08:32:44 CST 2021, time=2021-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004667, encodeId=d5c0100466e48, content=不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210802/3669f4a8902c468db74ad8a38daea6fe/4bc0307225d14145870d332d64dc7211.jpg, createdBy=01e45562049, createdName=月儿005, createdTime=Mon Aug 02 16:02:55 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593346, encodeId=a9f01593346d5, content=<a href='/topic/show?id=8d1342e95fa' target=_blank style='color:#2F92EE;'>#外周动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42795, encryptionId=8d1342e95fa, topicName=外周动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b27818121614, createdName=wujh_7312825, createdTime=Fri Apr 09 10:32:44 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604050, encodeId=9cbb1604050fd, content=<a href='/topic/show?id=67b81023e6ea' target=_blank style='color:#2F92EE;'>#高强度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102376, encryptionId=67b81023e6ea, topicName=高强度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79d219134728, createdName=aids219, createdTime=Fri Apr 09 10:32:44 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036563, encodeId=94d810365638c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Apr 07 22:32:44 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050349, encodeId=517c1050349d9, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Wed Apr 07 22:32:44 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955022, encodeId=311b95502286, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=528a5423951, createdName=ms2000000575280257, createdTime=Wed Apr 07 19:38:31 CST 2021, time=2021-04-07, status=1, ipAttribution=)]
    2021-04-09 aids219
  6. [GetPortalCommentsPageByObjectIdResponse(id=1654844, encodeId=5b961654844ff, content=<a href='/topic/show?id=4eb6632899b' target=_blank style='color:#2F92EE;'>#步行#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63289, encryptionId=4eb6632899b, topicName=步行)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5524567114, createdName=yuanming15, createdTime=Tue Aug 17 00:32:44 CST 2021, time=2021-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058132, encodeId=d6bc205813236, content=<a href='/topic/show?id=d104201831a' target=_blank style='color:#2F92EE;'>#下肢外周动脉疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20183, encryptionId=d104201831a, topicName=下肢外周动脉疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Fri Dec 10 08:32:44 CST 2021, time=2021-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004667, encodeId=d5c0100466e48, content=不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210802/3669f4a8902c468db74ad8a38daea6fe/4bc0307225d14145870d332d64dc7211.jpg, createdBy=01e45562049, createdName=月儿005, createdTime=Mon Aug 02 16:02:55 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593346, encodeId=a9f01593346d5, content=<a href='/topic/show?id=8d1342e95fa' target=_blank style='color:#2F92EE;'>#外周动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42795, encryptionId=8d1342e95fa, topicName=外周动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b27818121614, createdName=wujh_7312825, createdTime=Fri Apr 09 10:32:44 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604050, encodeId=9cbb1604050fd, content=<a href='/topic/show?id=67b81023e6ea' target=_blank style='color:#2F92EE;'>#高强度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102376, encryptionId=67b81023e6ea, topicName=高强度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79d219134728, createdName=aids219, createdTime=Fri Apr 09 10:32:44 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036563, encodeId=94d810365638c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Apr 07 22:32:44 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050349, encodeId=517c1050349d9, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Wed Apr 07 22:32:44 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955022, encodeId=311b95502286, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=528a5423951, createdName=ms2000000575280257, createdTime=Wed Apr 07 19:38:31 CST 2021, time=2021-04-07, status=1, ipAttribution=)]
    2021-04-07 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1654844, encodeId=5b961654844ff, content=<a href='/topic/show?id=4eb6632899b' target=_blank style='color:#2F92EE;'>#步行#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63289, encryptionId=4eb6632899b, topicName=步行)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5524567114, createdName=yuanming15, createdTime=Tue Aug 17 00:32:44 CST 2021, time=2021-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058132, encodeId=d6bc205813236, content=<a href='/topic/show?id=d104201831a' target=_blank style='color:#2F92EE;'>#下肢外周动脉疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20183, encryptionId=d104201831a, topicName=下肢外周动脉疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Fri Dec 10 08:32:44 CST 2021, time=2021-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004667, encodeId=d5c0100466e48, content=不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210802/3669f4a8902c468db74ad8a38daea6fe/4bc0307225d14145870d332d64dc7211.jpg, createdBy=01e45562049, createdName=月儿005, createdTime=Mon Aug 02 16:02:55 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593346, encodeId=a9f01593346d5, content=<a href='/topic/show?id=8d1342e95fa' target=_blank style='color:#2F92EE;'>#外周动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42795, encryptionId=8d1342e95fa, topicName=外周动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b27818121614, createdName=wujh_7312825, createdTime=Fri Apr 09 10:32:44 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604050, encodeId=9cbb1604050fd, content=<a href='/topic/show?id=67b81023e6ea' target=_blank style='color:#2F92EE;'>#高强度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102376, encryptionId=67b81023e6ea, topicName=高强度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79d219134728, createdName=aids219, createdTime=Fri Apr 09 10:32:44 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036563, encodeId=94d810365638c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Apr 07 22:32:44 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050349, encodeId=517c1050349d9, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Wed Apr 07 22:32:44 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955022, encodeId=311b95502286, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=528a5423951, createdName=ms2000000575280257, createdTime=Wed Apr 07 19:38:31 CST 2021, time=2021-04-07, status=1, ipAttribution=)]
    2021-04-07 jingjing

    运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少

    0

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    2021-04-07 ms2000000575280257

    学习了

    0

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Int J Cardiol:外周动脉疾病男性患者血运重建率较低和预后不良!

该研究的数据显示特别是在晚期PAD(CLI)患者中血运重建率较低。男性患者更多地通过外科手术进行血管再通,但较少使用血管内治疗,并且随访期间截肢率和死亡率较高。

JACC:外周动脉疾病抗栓治疗:整合与转化证据到临床的意义

动脉粥样硬化性心血管疾病在全球范围内影响2亿多成年人,而下肢外周动脉疾病(PAD)被认为是影响下肢动脉的全身动脉粥样硬化的表现。尽管近几十年来在诊断和治疗方面均取得了进展,但PAD患者中有5%~10%会复发,每年有数百万人死于心血管疾病。2018年1月,发表在《J Am Coll Cardiol》的一项由美国科学家进行的外周动脉疾病抗栓治疗综述,整合与转化证据到临床实践。

JAHA:人种和社会经济状况独立影响外周动脉疾病患者的截肢风险!

由此可见,在同一SES阶层的黑人与白种人相比截肢风险显著增加,并且在控制合并症、就诊时PAD严重程度和使用药物后,黑人人种对肢体损失具有独立的影响。

Circulation:紫杉醇涂层装置(PTXDs)使周围动脉疾病(PAD)患者**死亡风险增加4.6%!

紫杉醇涂层装置(PTXDs)常被用于周围动脉疾病(PAD)患者的股骨-腘动脉内介入手术,被认为可显著减少有症状的股腘周围动脉疾病患者的再干预。近期,一篇发表在《Circulation》上的汇总数据荟萃

Circulation:从全新高血压指南看血压与外周动脉事件的相关性

目前,指南建议治疗外周动脉疾病(PAD)患者的高血压,以降低心血管事件和卒中风险,但降低血压对下肢PAD事件的影响在很大程度上并不清楚。研究者使用抗高血压和降脂治疗预防心血管病发作试验(ALLHAT)数据,探讨血压与下肢PAD事件的关系。

Int J Cardiol:慢性肾脏病对接受血管内治疗的外周动脉疾病患者临床结局的影响!

由此可见,在真正的EVT时代,患有CKD的PAD患者的短期死亡率、短期意外截肢结局以及整体和无MALE生存率与无CKD的患者相比更差。这些发现可能为将接受EVT治疗的CKD患者提供额外的预后信息。