肿瘤科

订阅

MedSci主页 / 所有栏目 / 肿瘤科

SJO：化疗会促进肿瘤进化

2015-12-03 佚名 生物谷

化疗乳腺癌肿瘤金华基因突变
关注

一项刊登于国际杂志Siberian Journal of Oncology上的研究论文中，来自俄罗斯的科学家通过研究发现，对乳腺癌患者进行辅助化疗或可刺激肿瘤发生进化；文章中研究人员对准备进行手术的乳腺癌患者的活组织样本进行了分析，随后在每一份样本的活组织检查中都检测到了染色体的异常情况。 在患者手术进行之前，患者接受了2-4小时的辅助化

图片来源：medicalxpress.com

近日，一项刊登于国际杂志Siberian Journal of Oncology上的研究论文中，来自俄罗斯的科学家通过研究发现，对乳腺癌患者进行辅助化疗或可刺激肿瘤发生进化；文章中研究人员对准备进行手术的乳腺癌患者的活组织样本进行了分析，随后在每一份样本的活组织检查中都检测到了染色体的异常情况。

在患者手术进行之前，患者接受了2-4小时的辅助化疗（neoadjuvant chemotherapy，NAC），术后研究者进行了重复的分析来观察肿瘤的治疗效应；结果研究者发现，在大部分患者机体中，化疗会完全或部分破坏肿瘤的老巢，但23%的患者却表现出了在辅助治疗情况下出现肿瘤新生的情况，而且研究者还在部分肿瘤细胞中发现了染色体的加倍现象，而肿瘤细胞也因此产生了耐药性，这种现象称之为放大效应，即化疗产生的副作用，计划所有的患者都发生了癌症转移，其余的患者在5年的观察期内并未发生肿瘤转移。

研究者Ibragimova表示，在化疗的影响下有可能会刺激耐药性肿瘤的进化，使其对当前化疗的效应并没有任何反应；前期实验结果表明，化疗会促进突变产生，而这些突变在染色体区域的放大效应中并没有发现，在某些病例中这或许是癌症血原性转移发生的主要原因；研究者希望可以发现参与肿瘤发生的方法和原因，然而毫无疑问的是化疗存在严格的个性化特征，这主要依赖于肿瘤和患者的特性。

大多数的化疗药物都是固有的突变剂，而化疗可以引发肿瘤细胞出现遗传异常，这些遗传异常就会导致肿瘤细胞的改变，因此研究者观察到的肿瘤细胞的死灰复燃就是为了应对化疗的攻击，目前研究者正在尝试揭示肿瘤为何会在化疗效应下进化以及其进化的机制。研究者后期将增加样本量来检查上述表现，如果可以利用一种技术成功预测特殊患者机体中的肿瘤发育，那么就可以确定是否患者需要进行化疗以及哪种药物可以被使用。

本文研究对于帮助制定乳腺癌患者的个体化治疗方案提供了一定思路，比如化疗目前是肿瘤学家们治疗肿瘤的主要手段，而他们希望后期可以开发出更多新型的癌症治疗手段。

推荐阅读：

Chemotherapy can cause tumor evolution

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-27 hixiaoluo

    好文章，值得收藏

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-27 hixiaoluo

    好文章，值得收藏

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-06 三三五五

    有点像人突破重重困难，突出重围一样。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-06 三三五五

    生物进化论在这里也适用？

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-05 lovetcm

    相当于绞恐怖组织一样，相互增长的

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-05 Jianghuiqin

    不难理解！和放疗一样！

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-04 medcardio

    肿瘤进化能力超强

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-04 老段

    同意其观点

    0

相关资讯

Nature：为何化疗对某些胰腺癌失效了？

近日，刊登于国际著名杂志Nature上的一篇研究论文中，来自德州大学安德森癌症中心的科学家通过研究揭示了为何某些化疗药物，比如吉西他滨不能够有效治疗某些胰腺癌患者，该研究或为开发新型疗法通过增强吉西他滨的功效来阻断肿瘤生长提供希望。 文章中研究者通过对小鼠进行研究发现，抑制一种名为上皮细胞间质转型(EMT)的细胞可塑性过程同吉西他滨的结合或许就

BMJ：涨知识：化疗后指甲出现这种白色线条叫“米氏线”！——案例报道

67岁女性患有乳腺癌，在进行第五次辅助化疗前就诊，检查发现患者的指甲发生了如下变化，这是什么变化？什么原因导致指甲的这种改变？指甲上白色的线叫做“米氏线(Mees' lines)”，是由患者的化疗所致。米氏线是博氏线(Beau's lines)的一种变异，表现为手指甲、脚趾甲深沟槽的横向线条。在1919年第一次被荷兰医生R A Mees描述后命名。导致指甲出现米氏线的原因有：肾衰竭；疟疾；砷、铊或

BMJ：好恐怖！化疗导致指纹消失！——案例报道

47岁男性接受奥沙利铂和卡培他滨化疗治疗，他的手掌开始出现干燥和红斑。有一天，他的手指不能解锁自己的手机！（知道或用过iPhone的人都了解“指纹识别”解锁的吧。）他的指纹消失了！！！知道掌跖感觉丧失性红斑（PPE）吗？又称手足综合症（HFS），表现为手掌-足底发红感觉异常或化疗导致的四肢末端红斑，为化疗药物引起的一种皮肤毒副作用。使用卡培他滨化疗患者PPE发生率大约为53-57%，但是导致指纹消

JCO：乳腺癌新辅助化疗结局的种族差异

研究者进行了一项研究，探究乳腺癌新辅助化疗对不同种族人群的结局差异。该研究纳入了2010-2011年诊断为1-3期的乳腺癌患者，根据不同种族分组，收集化疗使用和病理完全缓解率 (pCR)等数据。共有278,815名患者已知其种族，127,417 (46%)名患者接受了化疗，121,446名患者明确化疗时机，27,300 (23%)名患者接受新辅助化疗。研究数据显示，黑人、西班牙裔和亚洲女性患者接受

JCO：地磷莫司治疗晚期子宫内膜癌是有效的，但毒副作用太大

复发或转移性子宫内膜癌女性预后非常差，治疗上的改善迫在眉睫。mTOR通路在该疾病中是很重要的靶位，并且mTOR抑制剂对子宫内膜癌的治疗有效。研究者进行了一项开放、多中心、随机2期试验，比较了口服地磷莫司和黄体酮或化疗（对照组）对复发或转移性子宫内膜癌患者（一二线化疗治疗后疾病进展，同时未进行激素治疗）的疗效情况。初始结局指标为无进展生存期 (PFS) 。该研究共纳入130名患者，其中64名口服地磷

JCO：基因分型确定化疗给药剂量

氟嘧啶类药物是重要的抗癌药物，被广泛地用于多种恶性实体瘤的辅助以及姑息治疗，比如胃肠道癌、乳腺癌以及头颈癌等等。此类药物有着较好的耐受性。只有大于5%-10%的患者在用药后会出现严重的，潜在的危及生命的毒性。对于这些严重毒性的治疗通常要求病人进行住院治疗。这会对病人的预后和生活质量带来巨大的影响，也会给病人带来巨大的经济负担。