盘点:2018年2月第3期BMJ研究精选

2018-02-22 zhangfan MedSci原创

BMJ

2018年2月第3期BMJ研究精选



【1】封面文章--深加工食物与肿瘤风险


近日研究人员对深加工食物与肿瘤风险之间的关系进行深入研究。

104980名参与者,平均年龄42.8岁,参与者完成至少两项24小时在线饮食问卷调查,旨在衡量3300种不同食物的常见摄入量。

结果显示,饮食中深加工食品比例增加10%,整体癌症风险增加12%,乳腺癌风险增加11%,但深加工食品与前列腺癌和结肠直肠癌无显著相关性。上述相关性在调整了脂质、盐、碳水化合物等相关饮食营养因素后仍十分显著。

【2】65岁以上慢性肾病患者服用抗凝血剂导致中风风险增加


近日研究人员发现,65岁以上慢性肾病患者服用抗凝血剂可能增加中风风险。

在基于人群的回顾性队列研究中,6977名65岁以上患有慢性肾病和新诊断房颤患者参与,其中2434人服用抗凝血剂,研究同时招募了2434名对照志愿者。对参与者进行了506天的中位数监测。在研究期间,服用抗凝血剂的参与者中风风险增加2.6倍,出血风险增加2.4倍。每100患者年中,使用抗凝剂或不适用抗凝剂患者,缺血性中风分别发生1.5例和0.4例。相对于未使用抗凝剂人群,使用患者中风、出血以及死亡风险分别为2.6、2.42以及0.82。

【3】单纯皮肤脓肿引流术后抗生素临床应用指南


1、对于非复杂性皮肤脓肿,指南建议在切口和引流的同时使用甲氧苄啶-磺胺甲恶唑(TMP-SMX)或克林霉素,而非单独切开和引流,指南特别强调药物应用对皮肤小脓肿的治疗效果;

2、TMP-SMX或克林霉素可温和地减少疼痛,降低治疗失败率,减少脓肿复发,但增加了恶心和腹泻等不良反应的风险;

3、指南推荐使用TMP-SMX而非克林霉素作为非复杂性皮肤脓肿的一线药物,因其腹泻风险较低;

4、在大多数情况下,在切开和引流同时服用头孢菌素类药物不会比单独切开和引流更有效;

5、任何情况下抗生素的使用均需要衡量耐药性与收益的风险

【4】妊娠偏头痛的处理


偏头痛是怀孕最常见的神经疾病之一,大多数患者可自愈。许多有过偏头痛发作史的妇女在怀孕期间症状会有所改善,尤其是与月经有关的偏头痛或无先兆偏头痛患者,而对于先兆偏头痛女性其症状发作往往难以预测。对于少数怀孕期间首次发生偏头痛的女性往往会伴有焦虑。

对于孕期头痛患者,区分偏头痛、紧张性头痛和丛生性头痛十分重要。此外,子痫前期与脑静脉血栓也会引起偏头痛,需进行急诊评估,但这种情况往往发生在孕12周之后。

研究证实大多数治疗和预防偏头痛方法在孕期应用是安全的。

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    2018-05-13 jyzxjiangqin

    BMJ研究精选.

    0

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    2018-05-01 jyzxjiangqin

    BMJ研究精选.

    0

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    2018-04-17 jyzxjiangqin

    BMJ研究精选.

    0

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    2018-04-08 jyzxjiangqin

    BMJ研究精选.

    0

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    2018-03-24 jyzxjiangqin

    BMJ研究精选.

    0

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    2018-11-14 gaoxiaoe
  7. [GetPortalCommentsPageByObjectIdResponse(id=314630, encodeId=c62f31463048, content=BMJ研究精选., beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun May 13 07:02:29 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310878, encodeId=3dbc3108e88f, content=BMJ研究精选., beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue May 01 07:09:27 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=306577, encodeId=1a993065e73f, content=BMJ研究精选., beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Apr 17 07:05:23 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303760, encodeId=4e64303e6055, content=BMJ研究精选., beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Apr 08 06:47:56 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299179, encodeId=8c312991e949, content=BMJ研究精选., beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Mar 24 07:17:57 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848469, encodeId=fe22184846944, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Wed Nov 14 05:12:00 CST 2018, time=2018-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296064, encodeId=472e296064ca, content=BMJ研究精选., beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 14 07:16:09 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292201, encodeId=c205292201e9, content=BMJ研究精选., beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Mar 02 07:29:05 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291846, encodeId=80082918465c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Thu Mar 01 03:26:26 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291841, encodeId=035d2918415e, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Thu Mar 01 03:00:21 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-03-14 jyzxjiangqin

    BMJ研究精选.

    0

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    2018-03-02 jyzxjiangqin

    BMJ研究精选.

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    2018-03-01 121832a9m88暂无昵称

    学习了

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    2018-03-01 lofter

    学习了感谢分享

    0

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