Diabetes Care：糖尿病对乳腺癌治疗和预后的影响！

2018-01-20 xing.T MedSci原创

由此可见，尽管患有糖尿病和不伴有糖尿病患者接受癌症治疗相似，但在糖尿病病程较长或已有心血管疾病的妇女中乳腺癌特异性死亡率仍然较高。这项研究揭示了糖尿病和乳腺癌患者预后不良的主要危险因素的新信息。

乳腺癌合并糖尿病的妇女比没有糖尿病的乳腺癌患者将面临更坏的结局；然而，合并症对这些差异的贡献仍不明确。近日，糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章，研究人员评估了糖尿病对癌症治疗和死亡率的影响，同时也考虑了其他合并症。

研究人员使用安大略行政数据库比较了患有糖尿病和不伴有糖尿病的妇女接受乳腺癌治疗的比率。在评估接受治疗和两组死亡结局的差异时，研究人员还进行了一项调整特定病因的风险模型来解释合并症。

糖尿病合并III期乳腺癌患者接受化疗的几率较小（相对风险（RR）为0.93（95%CI为0.89-0.97）），当对合并症进行调整时，这种差异并不显著（调整后的风险比（aHR）为1.03（95%CI为0.93-1.13））。研究人员在接受定向放射治疗上方面也观察到了类似趋势（RR为0.97 [0.95-0.99]，aHR为0.98[0.94-1.02]）。在调整合并症后（aHR为1.16（1.06-1.27）），糖尿病患者全因死亡率增加，但乳腺癌特异性死亡率总体上没有增加。糖尿病病程较长的妇女和已有心血管疾病的妇女全因和癌症特异性死亡率有所增加。

由此可见，尽管患有糖尿病和不伴有糖尿病患者接受癌症治疗相似，但在糖尿病病程较长或已有心血管疾病的妇女中乳腺癌特异性死亡率仍然较高。这项研究揭示了糖尿病和乳腺癌患者预后不良的主要危险因素的新信息。

原始出处：

Iliana C. Lega, et al. The Impact of Diabetes on Breast Cancer Treatments and Outcomes: A Population-Based Study.Diabetes Care.2018. https://doi.org/10.2337/dc17-2012

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2018-04-15 ms5439512287675881

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2018-05-04 木头人513

#Diabetes#

0 0
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2018-02-11 方舒

学习

53 0
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2018-02-01 大爰

学习了谢谢分享!!

54 0
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2018-01-25 三生有幸9135

学习一下谢谢分享

55 0
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2018-01-24 大爰

学习了谢谢分享!!

49 0
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2018-01-20 1ddf0692m34(暂无匿称)

学习了.涨知识

44 0
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2018-01-20 惠映实验室

学习了.谢谢分享.

24 0

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