Diabetes Care:胰岛素新发现或可逆转糖尿病

2017-06-23 Heather_z727 来宝网

近日,来自瑞典乌普萨拉大学研究人员的研究结果发表于《糖尿病护理》的在线杂志中,在文章中,研究人员详细阐述了他们的发现,很多患糖尿病超过10年的1型糖尿病患者身体中仍然会分泌胰岛素。



许多糖尿病患者可以产生胰岛素】近日,来自瑞典乌普萨拉大学研究人员的研究结果发表于糖尿病护理》的在线杂志中,在文章中,研究人员详细阐述了他们的发现,很多患糖尿病超过10年的1型糖尿病患者身体中仍然会分泌胰岛素。

1型糖尿病是一种慢性疾病,高发人群为儿童或青少年,医学界曾认为“不产生”胰岛素是导致1型糖尿病的直接原因,然而近些年来,通过使用先进的胰岛素化验,科学家已经证明这并不是导致所有1型糖尿病的直接原因。

在乌普萨拉大学的这项研究中,研究人员对100多名1型糖尿病患者进行了调查,其中一半成人患者已经有至少十年的1型糖尿病史,然而,他们的身体中仍会产生一些胰岛素。

研究显示了“完全不产生”胰岛素的患者与“还在产生”胰岛素的患者免疫系统存在着很大的差异。可以分泌胰岛素的患者interleukin-35血糖水平更高,这是免疫系统中一种抗炎性信号蛋白,除此之外,他们产生interleukin-35的免疫细胞更多,抑制免疫攻击更大。

现在还不清楚的是,患者在得病的时候interleukin-35水平就更高,还是多年来,这一水平持续增高。厘清这一问题,可以预防糖尿病的发展。通过interleukin-35与1型糖尿病的关系,有望逆转1型糖尿病。

接下来,乌普萨拉大学已经启动了1型糖尿病新药的开发,通过诱导胰岛素再生,逆转糖尿病。

原始出处:

Daniel Espes, Kailash Singh, Stellan Sandler, et al. Increased Interleukin-35 Levels in Patients With Type 1 Diabetes With Remaining C-Peptide. Diabetes Care 2017 Jun; dc162121. https://doi.org/10.2337/dc16-2121.

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1921176, encodeId=3cb519211e67f, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sat Oct 28 05:34:00 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901693, encodeId=7de1190169361, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Tue Oct 10 20:34:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637845, encodeId=f221163e84589, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue May 08 12:34:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760047, encodeId=5e0e1e60047e8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Nov 03 17:34:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749762, encodeId=ef4c1e49762ed, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sat Oct 28 08:34:00 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214737, encodeId=1346214e379c, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Jun 24 10:04:04 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214563, encodeId=51c021456368, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Jun 24 01:03:38 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-10-28 baoya
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    2017-06-24 thlabcde

    好东西学习了!

    0

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    2017-06-24 惠映实验室

    学习了,谢谢分享

    0

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杰克逊实验室,Cyteir治疗公司和合作机构的研究人员已经找到了一种方法来保护胰腺β细胞免受破坏——实现长期难以捉摸的目标,可能带来预防1型糖尿病(T1D)的治疗方法。