Diabetes Care:科学家找到导致心血管疾病不断增加的“罪魁祸首”

2017-06-21 Heather_z727 来宝网

近日,在线发表于《糖尿病护理》上的文章指出,近些年来,女性以及青少年1型糖尿病患者的原蛋白转化酶枯草杆菌蛋白酶类型9(PCSK9)逐渐增加。



女性和1型糖尿病青少年PCSK9水平增加】近日,在线发表于《糖尿病护理》上的文章指出,近些年来,女性以及青少年1型糖尿病患者的原蛋白转化酶枯草杆菌蛋白酶类型9(PCSK9)逐渐增加。

来自哈佛医学院的医学博士和他的同事们测量了年轻人以及女性1型糖尿病的PCSK9水平,并与先前描述的这一群体人们的PCSK9水平进行对比。研究人员检查了PCSK9和年龄,身体质量指数,糖化血红蛋白,血压,甘油三酯,胆固醇和载脂蛋白B之间的关系,数据来自74名平均年龄15.4岁的健康青少年和176名平均年龄15.2岁的1型糖尿病患者。

通过对比研究,研究人员发现,女性和年轻的1型糖尿病患者PCSK9浓度明显更高,在控制组,男性的PCSK9水平从187±67 ng / mL增加到215±83 ng / mL;女性则从253±98 ng / mL增加到 299±106 ng / mL。

PCSK9水平与总胆固醇有着密切的关系,除此之外,PCSK9还与糖化血红蛋白,甘油三酯,低密度脂蛋白胆固醇等都有着密不可分的关系。

研究人员表示:“近年来,心血管疾病的发病率逐年增高,特别是女性,这与PCSK9的水平异常是密不可分的,在未来的工作中,我们将进一步厘清PCSK9血脂异常的原因,彻底解决这些烦人的疾病。”

原始出处:

Amy E. Levenson, R. Paul Wadwa, Amy S. Shah, et al. PCSK9 Is Increased in Youth With Type 1 Diabetes. Diabetes Care 2017 Jun; dc162563. https://doi.org/10.2337/dc16-2563.

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    2017-06-26 lou.minghong

    应该提示一下这是个什么东西。

    0

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