JCEM：刘伟教授发现多囊卵巢综合征患者脂代谢特征

2016-12-14 MedSci MedSci原创

临床内分泌领域的权威杂志美国The Journal of Clinical Endocrinology & Metabolism（《临床内分泌与代谢杂志》）在线发表了中国科学院上海生命科学研究院营养科学研究所尹慧勇组与上海交通大学附属仁济医院内分泌代谢科刘伟组合作的研究成果：Discovery of novel lipid profiles in PCOS: Do insulin and

临床内分泌领域的权威杂志美国The Journal of Clinical Endocrinology & Metabolism（《临床内分泌与代谢杂志》）在线发表了中国科学院上海生命科学研究院营养科学研究所尹慧勇组与上海交通大学附属仁济医院内分泌代谢科刘伟组合作的研究成果：Discovery of novel lipid profiles in PCOS: Do insulin and androgen oppositely regulate bioactive lipid production?。该研究揭示了不同表型多囊卵巢综合征患者血清脂质谱的特点。

多囊卵巢综合征（PCOS）是在青春期及生育年龄妇女人群中常见的多系统综合征。最新流行病学调查研究显示，我国育龄妇女PCOS的发病率约为5.6%,并有逐年增高的趋势。PCOS主要表现为稀发排卵／不排卵、多囊卵巢、高雄激素血症，多伴有糖脂等多种代谢异常，显著增加罹患糖尿病、冠心病、子宫内膜癌等风险，严重影响女性生育健康。但目前有关多囊卵巢综合征的发病机制仍不清楚,临床干预手段也十分有限。

在本研究中，研究人员在初诊尚未进行药物干预的PCOS患者群中运用GC-MS/MS和LC-MS/MS等脂质组学技术检测了血清脂质谱，研究发现：肥胖伴脂肪肝的PCOS患者存在磷脂酰胆碱（PC）代谢异常，导致血清PC（16:0/18:0/18:1-18:2/20:4）升高，溶血磷脂酰胆碱（LPC）（16:0，18:0，18:1）下降，而非肥胖的PCOS患者变化不显著；肥胖的PCOS患者血清多不饱和脂肪酸（PUFAs）下降，而长链饱和脂肪酸（LSFAs）显著高于对照；PCOS患者血清中的PUFAs代谢产物（尤其是花生四烯酸的代谢产物）显著降低，这一现象在PCOS大鼠模型中也得到了验证。由于PCOS患者存在高雄激素和高胰岛素血症，推测雄激素和胰岛素对PUFAs代谢的不同作用导致了血清PUFAs代谢产物的改变。鉴于PGE2、PGF2a和PGI2在卵泡发育、成熟、排卵、受精和胚胎着床等生殖过程中的重要作用，本研究为深入探讨PCOS的发病机制和寻找新的治疗靶标提供了线索。

PCOS病人血清中脂代谢产物的变化谱图

原始出处：

Li S, Chu Q, Ma J, Sun Y, Tao T, Huang R, Liao Y, Yue J, Zheng J, Wang L, Xue X, Zhu M, Kang X, Yin H, Liu W. Discovery of novel lipid profiles in PCOS: Do insulin and androgen oppositely regulate bioactive lipid production? J Clin Endocrinol Metab. 2016 Nov 25:jc20162692

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#插入话题

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2017-03-31 kalseyzl

#多囊卵巢#

28 0
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2017-06-05 achengzhao

#JCE#

29 0
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2017-11-07 smallant2015

#JCEM#

33 0
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2016-12-17 1e0f8f00m85(暂无匿称)

有意思的study

43 0
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2016-12-16 zhouqu_8

#综合征#

30 0
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2016-12-16 huangdf

#脂代谢#

30 0
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2016-12-15 1e1b1150m51(暂无匿称)

思路很好

40 0
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2016-12-14 知难而进

谢谢分享！

42 0

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