Clin Gastroenterology H: 外阴不适与炎性肠病活动之间的关联

2020-02-23 不详 MedSci原创

炎症性肠病(IBD)在美国每100000人中有200-400人发病,其中大约一半是妇女,本项研究旨在确定女性的外阴阴道症状的发生率以及与IBD活性的相关性。

背景与目标
炎症性肠病(IBD)在美国每100000人中有200-400人发病,其中大约一半是妇女,本项研究旨在确定女性的外阴阴道症状的发生率以及与IBD活性的相关性。

方法
患有IBD的18岁以上女性(1250)完成了一项在线调查,查询是否存在外阴或阴道瘙痒,烧伤或刺激,白带或干燥以及外阴阴道疼痛和严重程度。该调查收集了有关人口统计学特征和IBD活动的信息(使用曼尼托巴指数进行了分类)。使用双变量分析比较有症状和无症状的妇女。Logistic回归评估IBD严重程度与外阴症状之间的相关性,并根据诊断,更年期,吸烟,抑郁和使用药物治疗IBD进行调整。

结果
共有512名(41%)妇女报告了至少1种中度至重度外阴阴道症状。活动性IBD女性除阴道干燥外所有外阴症状均较常见。在控制更年期,吸烟,PROMIS抑郁仪的t评分和使用IBD药物的多变量模型中,根据马尼托巴指数评分,具有恒定或频繁活动性IBD的女性发生中度至重度外阴阴道症状的几率增加(几率比率为1.68; 95%CI为1.22-2.32)。外阴不适经常或总是减少对性生活的兴趣(n = 336;28%)或性能力(n = 207; 16%)。

结论
本项研究发现与缓解期女性相比,IBD活跃度更高的女性外阴不适的患病率有所增加。这些症状影响性健康。

原始出处:
Samsiya Ona. Et al. Association Between Vulvovaginal Discomfort and Activity of Inflammatory Bowel Diseases. Clinical Gastroenterology Hepatology. 2020.

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    2020-12-04 许安
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