JAHA:急性缺血性卒中后一年的血压变化轨迹

2022-02-24 MedSci原创 MedSci原创

急性缺血性卒中患者1年内收缩压可有4中纵向变化轨迹。收缩压缓慢下降和收缩压持续较高组的患者在卒中后容易出现不良心血管结局。

临床医生习惯于在一天中的某个时间点测量血压,但可能未充分考虑血压随时间的纵向变化或血压变化轨迹。血压的变化轨迹这一血压指标主要基于社区居民队列来获得,并且获取了受试者一生中的纵向血压变化。这些研究表明,高血压持续控制不佳的个体发生血管事件或死亡的风险更高。虽然血压对卒中患者结局的影响已得到广泛关注,但急性缺血性卒中后血压的长期变化轨迹及其对患者结局的影响尚未得到很好的归纳。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员分析了5514名急性缺血性卒中患者在卒中后第一年内进行2次以上收缩压测量的急性缺血性卒中患者,这些患者均来自于多中心前瞻性登记中心。研究人员使用基于组的轨迹模型对纵向收缩压进行分类。该研究的主要结局是卒中复发、心肌梗死和卒中后长达1年的全因死亡率的复合结局。

研究对象根据收缩压变化轨迹分为4个组别:低(27.0%)、中等(59.5%)、持续高(1.2%)和缓慢下降(12.4%)四组。在前3组中,收缩压在前3天下降,之后保持稳定。

在缓慢下降的收缩压组别中,前30天收缩压从182降至135mmHg,然后与中度收缩压组的轨迹平行。与对照组相比,中度收缩压组、缓慢下降的收缩压组在主要结局(调整后的风险比[HR]为1.32;95%CI为1.05-1.65)和死亡(调整后的HR为1.35;95%CI为1.03-1.78)风险更高。持续高收缩压组的主要结局发生率同样较高。

由此可见,急性缺血性卒中患者1年内收缩压可有4中纵向变化轨迹。收缩压缓慢下降和收缩压持续较高组的患者在卒中后容易出现不良心血管结局。

原始出处:

Keon‐Joo Lee.et al.One‐Year Blood Pressure Trajectory After Acute Ischemic Stroke.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.023747

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