Stroke:急性缺血性卒中、左心室射血分数和窦性心律的关系

2022-01-30 MedSci原创 MedSci原创

近5%的AIS患者LVEF降低且处于窦性心律。根据队列地区和卒中严重程度,抗血栓治疗的临床实践存在显著差异。鉴于这种临床平衡,需要进一步研究来明确该患者群体二级卒中预防的最佳抗血栓治疗方案。

有关急性缺血性卒中(AIS)后左心室射血分数(LVEF)和窦性心律降低的患者的流行病学和二级卒中预防策略的数据十分有限。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员试图描述2002年至2018年期间多中心队列中AIS和抗血栓治疗患者LVEF≤40%和窦性心律的患病率。

这是一项多中心、回顾性队列研究,纳入了在大辛辛那提北肯塔基卒中研究中住院的AIS患者和美国4个以医院为基础的学术队列。研究人员进行一期荟萃分析以计算汇总患病率,并进行单变量分析和调整的多变量Logistic回归模型,以确定与AIS出院时抗凝剂治疗相关的人口统计学、临床和超声心动图特征。

在卒中住院期间记录有LVEF的14338名AIS患者中,LVEF≤40%和窦性心律的加权汇总患病率为5.0%(95%CI为4.1-6.0%;I2为84.4%)。在出院后幸存的524名无心脏血栓且既往无抗凝适应症的患者中,200名(38%)患者出院接受抗凝治疗,289名(55%)患者仅接受抗血小板治疗,35名(7%)患者均未接受抗凝治疗。研究人员使用抗凝剂出院的比例存在不同地区的异质性(22% vs. 45%,P<0.0001)。队列地区和美国国立卫生研究院卒中严重程度量表得分>8(比值比为2.0[95%CI为1.1-3.8])在调整分析中是出院时接受抗凝剂治疗的显著独立预测因素。

由此可见,近5%的AIS患者LVEF降低且处于窦性心律。根据队列地区和卒中严重程度,抗血栓治疗的临床实践存在显著差异。鉴于这种临床平衡,需要进一步研究来明确该患者群体二级卒中预防的最佳抗血栓治疗方案。

原始出处:

Anna D. Baker.et al.Acute Ischemic Stroke, Depressed Left Ventricular Ejection Fraction, and Sinus Rhythm: Prevalence and Practice Patterns.stroke.2022.https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.036706

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    Good

    0

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    2022-01-30 查查佳佳

    杂志Stroke上发表了一篇研究文章,

    0

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