Kaplan-Meier生存分析中三种检验方法(log-rank、breslow、tarone)的比较

2016-02-01 王江源 王江源

在Kaplan-Meier生存分析中有三种检验方法:log-rank、breslow、tarone。有时候会出现三种检验方法结果不一致的情况,到底取哪一个结果呢?我查阅了一些统计学书籍,给出的解释大致是这样:Log rank:检验生存分布是否相同,各时间点权重一样。Breslow:检验生存分布是否相同,以各时间点的观察例数为权重。Tarone-Ware:检验生存分布是否相同,以各时间点的观察例数的

SPSS中的分析方法的名称为Log Rank和Breslow;SAS中相对应的为Log Rank和Wilcoxon。Breslow法即广义Wilcoxon法。Log Rank检验在实际工作中应用较多。在Kaplan-Meier生存分析中有三种检验方法:log-rank、breslow、tarone。有时候会出现三种检验方法结果不一致的情况,到底取哪一个结果呢?我查阅了一些统计学书籍,给出的解释大致是这样:Log rank:检验生存分布是否相同,各时间点权重一样。Breslow:检验生存分布是否相同,以各时间点的观察例数为权重。Tarone-Ware:检验生存分布是否相同,以各时间点的观察例数的平方根为权重。Log Rank检验给结局事件的远期差别更大的权重,即对远期差异敏感;而Breslow检验给结局事件的近期差别更大的权重。,tarone法介于两者之间。对于一开始靠得很近,随着时间的推移逐渐拉开的生存曲线,log-rank法较breslow法更容易得到显著性的结果;反之,对于一开始拉的很开,以后逐渐靠近的生存曲线,breslow法较log-rank法更容易获得统计学差异。如果log-

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  1. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwlM29ic8TDJMJOiarryMIZZhTjXxyRT9lffSWpWWcWojnL7ibJwcOn99ayict8FJ9ICYmNh9swD6R4E/0, createdBy=196f1683049, createdName=收获你的美, createdTime=Mon Feb 01 19:30:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62479, encodeId=b7e5624e925, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Mon Feb 01 15:20:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62446, encodeId=0a066244654, content=学习了,正需要呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5b91683812, createdName=vinson820801, createdTime=Mon Feb 01 13:48:00 CST 2016, time=2016-02-01, status=1, ipAttribution=)]
    2021-06-14 ms5000000400046131

    积分不足怎么办?

    0

  2. 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createdName=vinson820801, createdTime=Mon Feb 01 13:48:00 CST 2016, time=2016-02-01, status=1, ipAttribution=)]
    2016-06-24 tingtinggogo

    谢谢 还想咨询下 如果生存曲线有交叉的话,怎么办?是不是不能用Logrank检验了呀?能用Tarone吗?谢谢

    0

  3. 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createdName=vinson820801, createdTime=Mon Feb 01 13:48:00 CST 2016, time=2016-02-01, status=1, ipAttribution=)]
    2016-03-20 我恨你medsci

    谢谢,学习一下

    0

  4. 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createdBy=53c41636887, createdName=米蓝shiny, createdTime=Tue Feb 02 22:30:00 CST 2016, time=2016-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62569, encodeId=e57262569c5, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Mon Feb 01 20:36:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62552, encodeId=07ca62552ef, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwlM29ic8TDJMJOiarryMIZZhTjXxyRT9lffSWpWWcWojnL7ibJwcOn99ayict8FJ9ICYmNh9swD6R4E/0, createdBy=196f1683049, createdName=收获你的美, createdTime=Mon Feb 01 19:30:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62479, encodeId=b7e5624e925, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Mon Feb 01 15:20:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62446, encodeId=0a066244654, content=学习了,正需要呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5b91683812, createdName=vinson820801, createdTime=Mon Feb 01 13:48:00 CST 2016, time=2016-02-01, status=1, ipAttribution=)]
    2016-02-24 撒哈拉的灵魂

    终于搞懂了

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwlM29ic8TDJMJOiarryMIZZhTjXxyRT9lffSWpWWcWojnL7ibJwcOn99ayict8FJ9ICYmNh9swD6R4E/0, createdBy=196f1683049, createdName=收获你的美, createdTime=Mon Feb 01 19:30:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62479, encodeId=b7e5624e925, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Mon Feb 01 15:20:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62446, encodeId=0a066244654, content=学习了,正需要呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5b91683812, createdName=vinson820801, createdTime=Mon Feb 01 13:48:00 CST 2016, time=2016-02-01, status=1, ipAttribution=)]
    2016-02-03 风铃824
  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwlM29ic8TDJMJOiarryMIZZhTjXxyRT9lffSWpWWcWojnL7ibJwcOn99ayict8FJ9ICYmNh9swD6R4E/0, createdBy=196f1683049, createdName=收获你的美, createdTime=Mon Feb 01 19:30:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62479, encodeId=b7e5624e925, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Mon Feb 01 15:20:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62446, encodeId=0a066244654, content=学习了,正需要呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5b91683812, createdName=vinson820801, createdTime=Mon Feb 01 13:48:00 CST 2016, time=2016-02-01, status=1, ipAttribution=)]
    2016-02-02 米蓝shiny

    赞?

    0

  7. 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createdName=vinson820801, createdTime=Mon Feb 01 13:48:00 CST 2016, time=2016-02-01, status=1, ipAttribution=)]
    2016-02-01 jiangxianchen

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=973478, encodeId=998e9e347828, content=积分不足怎么办?, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=e70a5418933, createdName=ms5000000400046131, createdTime=Mon Jun 14 16:00:26 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91050, encodeId=bc359105060, content=谢谢 还想咨询下 如果生存曲线有交叉的话,怎么办?是不是不能用Logrank检验了呀?能用Tarone吗?谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep4ZVG73J7KicD6ZgIgAib65f07YkpOFNnnow0TYVpicWySHQJT7ypxp0B0Bfnv0zGeueOdPJicdDe5kQ/132, createdBy=50e51613319, createdName=tingtinggogo, createdTime=Fri Jun 24 21:45:00 CST 2016, time=2016-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71987, encodeId=bce3e1987b8, content=谢谢,学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qibfM38xibA2YljABYPC0esPQj1fY87F66jH3bZDCFcv3alKYaibe46AJNMHib174Sa8XlkpeQiamKhrxHKqeaoGuVQ/132, createdBy=aeb81702398, createdName=我恨你medsci, createdTime=Sun Mar 20 10:58:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65502, encodeId=375365502eb, content=终于搞懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150821/IMG55D6B39CBF8E39654.jpg, createdBy=de3e1644070, createdName=撒哈拉的灵魂, 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createdBy=53c41636887, createdName=米蓝shiny, createdTime=Tue Feb 02 22:30:00 CST 2016, time=2016-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62569, encodeId=e57262569c5, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Mon Feb 01 20:36:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62552, encodeId=07ca62552ef, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwlM29ic8TDJMJOiarryMIZZhTjXxyRT9lffSWpWWcWojnL7ibJwcOn99ayict8FJ9ICYmNh9swD6R4E/0, createdBy=196f1683049, createdName=收获你的美, createdTime=Mon Feb 01 19:30:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62479, encodeId=b7e5624e925, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Mon Feb 01 15:20:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62446, encodeId=0a066244654, content=学习了,正需要呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5b91683812, createdName=vinson820801, createdTime=Mon Feb 01 13:48:00 CST 2016, time=2016-02-01, status=1, ipAttribution=)]
    2016-02-01 收获你的美

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=973478, encodeId=998e9e347828, content=积分不足怎么办?, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=e70a5418933, createdName=ms5000000400046131, createdTime=Mon Jun 14 16:00:26 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91050, encodeId=bc359105060, content=谢谢 还想咨询下 如果生存曲线有交叉的话,怎么办?是不是不能用Logrank检验了呀?能用Tarone吗?谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep4ZVG73J7KicD6ZgIgAib65f07YkpOFNnnow0TYVpicWySHQJT7ypxp0B0Bfnv0zGeueOdPJicdDe5kQ/132, createdBy=50e51613319, createdName=tingtinggogo, createdTime=Fri Jun 24 21:45:00 CST 2016, time=2016-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71987, encodeId=bce3e1987b8, content=谢谢,学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qibfM38xibA2YljABYPC0esPQj1fY87F66jH3bZDCFcv3alKYaibe46AJNMHib174Sa8XlkpeQiamKhrxHKqeaoGuVQ/132, createdBy=aeb81702398, createdName=我恨你medsci, createdTime=Sun Mar 20 10:58:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65502, encodeId=375365502eb, content=终于搞懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150821/IMG55D6B39CBF8E39654.jpg, createdBy=de3e1644070, createdName=撒哈拉的灵魂, createdTime=Wed Feb 24 22:31:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1509511, encodeId=c467150951191, content=<a href='/topic/show?id=6a8e264431' target=_blank style='color:#2F92EE;'>#APL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2644, encryptionId=6a8e264431, topicName=APL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c81c10095307, createdName=风铃824, createdTime=Wed Feb 03 01:26:00 CST 2016, time=2016-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62938, encodeId=91c96293868, content=赞?, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160609/IMG5759854C1517F8973.jpg, createdBy=53c41636887, createdName=米蓝shiny, createdTime=Tue Feb 02 22:30:00 CST 2016, time=2016-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62569, encodeId=e57262569c5, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Mon Feb 01 20:36:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62552, encodeId=07ca62552ef, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwlM29ic8TDJMJOiarryMIZZhTjXxyRT9lffSWpWWcWojnL7ibJwcOn99ayict8FJ9ICYmNh9swD6R4E/0, createdBy=196f1683049, createdName=收获你的美, createdTime=Mon Feb 01 19:30:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62479, encodeId=b7e5624e925, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Mon Feb 01 15:20:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62446, encodeId=0a066244654, content=学习了,正需要呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5b91683812, createdName=vinson820801, createdTime=Mon Feb 01 13:48:00 CST 2016, time=2016-02-01, status=1, ipAttribution=)]
    2016-02-01 李继凯

    赞一个

    0

  10. 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createdName=vinson820801, createdTime=Mon Feb 01 13:48:00 CST 2016, time=2016-02-01, status=1, ipAttribution=)]
    2016-02-01 vinson820801

    学习了,正需要呢

    0

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