Cell Stem Cell:胎儿造血干细胞的产生离不开胆汁酸!

2016-02-01 Mechront 译 MedSci原创

瑞典隆德大学的研究表明,通过胎盘从母亲转移到胎儿的胆汁酸使胎儿能够产生造血干细胞。医学实验室的研究者Kenichi Miharada在先前就证实了,在细胞培养时添加胆汁酸,可以减少内质网的化学性应激。而胆汁酸是肝脏产生储存在胆囊的物质,可以支持细胞分裂过程中所需蛋白质的生成。Kenichi Miharada说:“与其他试图通过干细胞治疗血液系统疾病的方法而言,这种方法是安全和快速的,胆汁酸是存在于

瑞典隆德大学的研究表明,通过胎盘从母亲转移到胎儿的胆汁酸使胎儿能够产生造血干细胞

医学实验室的研究者Kenichi Miharada在先前就证实了,在细胞培养时添加胆汁酸,可以减少内质网的化学性应激。而胆汁酸是肝脏产生储存在胆囊的物质,可以支持细胞分裂过程中所需蛋白质的生成。

Kenichi Miharada说:“与其他试图通过干细胞治疗血液系统疾病的方法而言,这种方法是安全和快速的,胆汁酸是存在于人体内的自然物质,不是人造物质,不涉及任何基因修饰。”

成人体内产生的胆汁酸主要用于食物的消化,研究者对妊娠老鼠的研究发现,胎儿体内也存在大量的胆汁酸。胎儿自身可以产生的胆汁酸数量有限、很少,而观察到的大量胆汁酸则来自于母体,母体产生的胆汁酸通过胎盘传递给胎儿。

虽然胆汁酸的大部分物质具有细胞毒性,但是通过胎盘之后,只有对胎儿无害的物质才能进入胎儿体内。Kenichi Miharada发现胆汁酸可以支持胎儿肝脏造血干细胞的生成,并使其正常分化。因此从母体获得的额外的胆汁酸对胎儿正常发育而言,是十分重要的!

Kenichi Miharada说:“如果胎盘损坏或病变,导致胎儿无法从母体获得足够的胆汁酸,进而在日后患上白血病或其他血液系统疾病。在接下来的日子,我们将对这一线索进行更多的研究。”

原始出处:

Bile acids protect expanding hematopoietic stem cells from unfolded protein stress in fetal liver, Valgardur Sigurdsson, Hajime Takei, Svetlana Soboleva, Visnja Radulovic,et al. Cell Stem Cell,doi:10.1016/j.stem.2016.01.002, published online 28 January 2016.

Bile acid support the production of blood stem cells

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    2016-03-19 维他命
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    2016-02-03 俅侠
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最近,瑞士洛桑理工学院(EPFL)的科学家发现,一种由胆汁酸激活的受体,能够降低脂肪组织炎症和肥胖相关糖尿病中的胰岛素抵抗。 全球流行的肥胖与2型糖尿病的增加有关,2型糖尿病起因于身体不能有效地利用胰岛素。肥胖者往往在他们的脂肪组织中发展炎症,反过来这可能会减少脂肪细胞对胰岛素的敏感性,从而导致2型糖尿病。EPFL科学家,与意大利和荷兰的研究人员合作表明,胆汁酸可激活一种鲜为人知的受体,

Gut:胆汁酸浓度可成为IBS诊断及疗效判定指标

肠易激综合症(IBS)是最常见的胃肠道功能紊乱性疾病之一,西方20%的人群受其影响。目前认为胃肠道免疫功能紊乱及肠道菌群失调可能是部分IBS患者的致病因素。有学者提出:胆酸能影响到内脏敏感性且能通过影响结肠运动、感觉功能影响IBS患者;已有通过调节肠道内胆酸浓度进而治疗IBS的报道。 结肠内胆酸浓度过高可通过影响结肠运动及分泌功能,导致水样便及排便习惯异常,一系统回顾研究发现IBS腹泻型患者及功

J Clin Invest:胆汁酸能够治疗糖尿病

近日,来自瑞士洛桑联邦理工大学的科学家与来自意大利和荷兰的研究人员共同发现:胆汁酸能够激活一个鲜为人知的受体来克服脂肪细胞对胰岛素敏感度的丧失,这种机制或能用于发展一种新型药物来治疗2型糖尿病。本研究成果题为“TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation”于近日发表在th