Arthritis Rheumatol:症状性手部骨关节炎的终生风险

2017-06-09 xiangting MedSci原创

症状性手部OA整体对社会人口学和临床亚组的巨大负担。需要更多地利用公共卫生和临床干预来解决其影响。

症状性手部骨关节炎(OA)是一种影响手部力量和功能的常见疾病,可导致日常生活中的残疾。之前的研究估计症状性膝关节OA的终生风险为45%,髋关节OA的终生风险为25%。这项研究的目的是估计症状性手部OA的终生风险,并根据潜在的危险因素对终生风险进行分层。

数据来自约翰斯顿县骨关节炎项目中的2218例成年受试者(年龄≥45岁),这是一项基于人群的前瞻性队列研究。这项研究的数据来自2个随访周期(1999-2004年和2005-2010年)。症状性手部OA被定义为同一手中同时存在自我报告的症状和影像学OA。使用广义估计方程的模型估计终生风险,终生风险定义为到85岁时至少1只手出现症状性手部OA的人口比例。

总体而言,症状性手部OA的终生风险为39.8%(95%置信区间[95%CI] 34.4-45.3%)。在这个人群中,近1/2的女性(47.2%,95%CI 40.6-53.9%)到85岁时有出现手部OA的风险,而男性为1/4(24.6%,95%CI 19.5-30.5%)。种族特异性症状手部OA风险估计为白人41.4%(95%CI 35.5-47.6%),非裔美国人29.2%(95%CI为20.5-39.7%)。肥胖个体(47.1%,95%CI 37.8-56.7%)症状性手部OA的终生风险比无肥胖个体高出11个百分点(36.1%,95%CI为29.7-42.9%)。

这些发现表明症状性手部OA整体对社会人口学和临床亚组的巨大负担。需要更多地利用公共卫生和临床干预来解决其影响。

原始出处:
Jin Qin, Kamil E. Barbour, Louise B. Murphy,et al. Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project. Arthritis Rheumatol. June 2017.

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    2017-11-07 lisa438
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    2017-06-11 lmm397
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    2017-06-11 zhaojie88
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    2017-06-09 月吟凤歌

    一起来学习吧

    0

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