J Gastroenterology: 质子泵抑制剂单一疗法可有效减轻与胃食管反流病相关的消化不良症状

2019-06-09 不详 MedSci原创

胃食管反流病(GERD)和功能性消化不良(FD)经常会同时发生在同一个患者身上。本研究比较了质子泵抑制剂(PPI)治疗GERD相关FD患者的疗效。

背景和目标
食管反流病(GERD)和功能性消化不良(FD)经常会同时发生在同一个患者身上。本研究比较了质子泵抑制剂(PPI)治疗GERD相关FD患者的疗效。

方法
研究人员对患有GERD和FD症状的患者在内镜检查后让其接受PPI治疗4周,并且使用食管反流和消化不良治疗效果和满意度测试在治疗4周之前和之后评估症状的严重程度和治疗反应。

结果
本项研究共纳入了233例病例,其中40例属于轻度,151例属于中度,42例属于严重症状。对每种症状的治疗前评分的分析显示,较高的GERD-SS评分与任何类型的FD评分的较高评分显着相关。4周的PPI治疗显着并显着缓解GERD / FD症状。最重要的是,相对于治疗前评分,治疗4周后每种症状的评分变化在具有更严重的GERD-SS的组中显着更大。

结论
与GERD症状相关的FD症状被认为是与胃酸相关的消化不良疾病,使用PPI单一疗法可以作为这些患者的首选治疗方案。

原始出处:

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    2019-10-18 许安
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encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Jul 08 01:19:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711972, encodeId=79d01e1197212, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon May 04 19:19:00 CST 2020, time=2020-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064737, encodeId=8f632064e3738, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Wed Jun 19 06:19:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948576, encodeId=16ce19485e6d7, content=<a href='/topic/show?id=87828339e7a' target=_blank style='color:#2F92EE;'>#胃食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83397, encryptionId=87828339e7a, topicName=胃食管)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Wed Dec 18 16:19:00 CST 2019, time=2019-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667356, encodeId=8f1f166e35695, content=<a href='/topic/show?id=03ab923565b' target=_blank style='color:#2F92EE;'>#质子泵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92356, encryptionId=03ab923565b, topicName=质子泵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=761326143554, createdName=shenxlcyp, createdTime=Wed Apr 22 09:19:00 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260702, encodeId=2c6c1260e0211, content=<a href='/topic/show?id=2f71834056f' target=_blank style='color:#2F92EE;'>#胃食管反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83405, encryptionId=2f71834056f, topicName=胃食管反流)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Jun 11 11:19:00 CST 2019, time=2019-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437441, encodeId=e14f143e44121, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Jun 11 11:19:00 CST 2019, time=2019-06-11, status=1, ipAttribution=)]
    2019-07-08 jklm09
  5. 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encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Jul 08 01:19:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711972, encodeId=79d01e1197212, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon May 04 19:19:00 CST 2020, time=2020-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064737, encodeId=8f632064e3738, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, 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createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Jun 11 11:19:00 CST 2019, time=2019-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437441, encodeId=e14f143e44121, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Jun 11 11:19:00 CST 2019, time=2019-06-11, status=1, ipAttribution=)]
  6. 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objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Wed Jun 19 06:19:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948576, encodeId=16ce19485e6d7, content=<a href='/topic/show?id=87828339e7a' target=_blank style='color:#2F92EE;'>#胃食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83397, encryptionId=87828339e7a, topicName=胃食管)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Wed Dec 18 16:19:00 CST 2019, time=2019-12-18, status=1, 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  7. 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    2019-06-11 zhouqu_8

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背景:非洲裔美国女性与欧裔美国女性相比,虽然肥胖率更高;但是胃食管反流病(GERD)及其合并症却在欧裔美国女性中更为普遍。随着肥胖的增加,随之而来是胰岛素抵抗,进而饮食中过量摄入大量营养素,导致女性更多的GERD患病率和更严重的病情。 目的:探究GERD是否与饮食中碳水化合物的摄入量有关,特别是膳食简单的碳水化合物摄入,以及GERD是否与胰岛素抵抗有关。 方法:研究纳入了144名肥胖女

J Gastroen Hepatol:特发性贲门失弛缓症导致自身免疫性疾病风险增加

研究认为特发性贲门失弛缓症与自身免疫性疾病存在密切的相关性

J Clin Gastro:食管动力、酸性反流以及抑酸药在非阻塞行吞咽困难中的作用分析

有相当多的非阻塞性吞咽困难患者呈现正常的食管高分辨率测压(HRM),同时患有胃食管反流病(GERD)的患者经常会抱怨存在吞咽困难的现象,本研究旨在评估食管动力以及质子泵抑制剂(PPI)在治疗此相关吞咽困难中的疗效。

Chest:胃食管反流病与特发性肺纤维化的关系

由此可见,GERD和IPF可能有关,但这种关联很可能受到混淆,尤其是吸烟。研究人员对关联估计的信心很低,因为这些数据完全来自病例对照研究。

Gastroenterology: 浅表性食管粘膜传入神经可能与非侵蚀性反流性疾病的食道烧灼感有关

目前关于胃食管返流疾病引起食管烧灼感的原因知之甚少,其中食管上皮损害与症状严重程度相关并不成正相关关系,非呃逆性反流病(NERD)患者与糜烂性反流病(ERD)或巴雷特食管(BE)患者的症状各不相同。 本项研究探索了了NERD,ERD和BE患者粘膜神经纤维的分布,并将结果与正常人群进行了比较。

恼人的GERD,治疗方法都在这里!

如果反复出现反酸、烧心等类似于喝刺激咳嗽药水的感觉,那么请注意,你可能得了胃食管反流病(gastroesophageal reflux disease, GERD)。GERD引起的一系列反酸、烧心等症状,大部分都是因为胃酸在作祟。今天就来谈谈GERD的治疗。