Am J Psychiat:焦虑增加是老年痴呆症的早期预警!

2018-01-13 佚名 medicalnewstoday

焦虑症在美国很普遍,每年大约有4000万成年人受到影响。然而,如果这些忧虑和恐惧的情绪不足以应付的话,很可能很危险。一项新的研究表明老年人焦虑症状的恶化可能更容易患上老年痴呆症。

焦虑症在美国很普遍,每年大约有4000万成年人受到影响。然而,如果这些忧虑和恐惧的情绪不足以应付的话,很可能很危险。一项新的研究表明老年人焦虑症状的恶化可能更容易患上老年痴呆症。

研究人员将老年人的焦虑症状与老年痴呆症相关的蛋白质水平增高联系起来。研究人员发现,越来越多的焦虑症状与β-淀粉样蛋白的水平有关,β淀粉样蛋白是一种与老年痴呆症有关的蛋白质,在正常认知功能的老年人的大脑中。

来自布莱根妇女医院的研究人员表明,焦虑症状上升可能是老年痴呆的早期症状这些发现最近发表在《美国精神病学杂志》上。

阿尔茨海默病是一种痴呆症,其症状是记忆和思维以及行为的改变。据估计,美国大约有550万人患有老年痴呆症,其中65岁以上的人约占540万。阿尔茨海默病的确切病因还不清楚,但科学家认为β淀粉样蛋白起关键作用。这是一种可以形成“斑块”的蛋白质,它可以阻止阿尔茨海默氏症患者大脑中的神经细胞通讯。这些斑块是该病的一个特征,研究表明,β-淀粉样蛋白水平的增加可能发生在阿尔茨海默氏症发病前10年。

根据这项新的研究,焦虑会使β淀粉样蛋白增加,这项研究包括270名年龄在62岁到90岁之间的成年人,他们的认知功能正常,他们都在研究基线时接受了正电子发射断层扫描,并在5年的随访期间每年进行一次,以确定他们大脑中β淀粉样蛋白的水平。采用30项老年抑郁量表评定成人焦虑、抑郁症状。

研究发现,在5年的随访中,焦虑症状增加的成年人大脑中的β淀粉样蛋白水平也较高。研究人员说,这表明焦虑症的恶化可能是阿尔茨海默病的早期征兆。“如果进一步的研究证实焦虑是一种早期指标,那么这不仅对早期发现患者,而且对治疗焦虑有可能减缓或预防早期疾病的进展都很重要。”
原始出处:
Nancy J. Donovan,Nancy J. Donovan, Gad A. Marshall,et al.Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults. The American Journal of Psychiatry.January 12, 2018.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1836175, encodeId=7cd618361e5b3, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Apr 10 10:00:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278524, encodeId=b56a2e85247a, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jan 14 23:04:21 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278456, encodeId=e2bd2e845674, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:55:45 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050444, encodeId=5bbf10504449f, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Jan 14 01:00:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278260, encodeId=dc062e8260f9, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Jan 13 23:49:59 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-04-10 Boyinsh
  2. [GetPortalCommentsPageByObjectIdResponse(id=1836175, encodeId=7cd618361e5b3, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Apr 10 10:00:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278524, encodeId=b56a2e85247a, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jan 14 23:04:21 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278456, encodeId=e2bd2e845674, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:55:45 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050444, encodeId=5bbf10504449f, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Jan 14 01:00:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278260, encodeId=dc062e8260f9, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Jan 13 23:49:59 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-01-14 131****2916

    不错的文章值得推荐

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1836175, encodeId=7cd618361e5b3, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Apr 10 10:00:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278524, encodeId=b56a2e85247a, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jan 14 23:04:21 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278456, encodeId=e2bd2e845674, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:55:45 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050444, encodeId=5bbf10504449f, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Jan 14 01:00:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278260, encodeId=dc062e8260f9, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Jan 13 23:49:59 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-01-14 虈亣靌

    谢谢分享.学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1836175, encodeId=7cd618361e5b3, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Apr 10 10:00:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278524, encodeId=b56a2e85247a, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jan 14 23:04:21 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278456, encodeId=e2bd2e845674, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:55:45 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050444, encodeId=5bbf10504449f, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Jan 14 01:00:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278260, encodeId=dc062e8260f9, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Jan 13 23:49:59 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-01-14 明天jing

    焦虑是当年年轻人的共同问题,需要认真对待。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1836175, encodeId=7cd618361e5b3, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Apr 10 10:00:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278524, encodeId=b56a2e85247a, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jan 14 23:04:21 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278456, encodeId=e2bd2e845674, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:55:45 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050444, encodeId=5bbf10504449f, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Jan 14 01:00:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278260, encodeId=dc062e8260f9, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Jan 13 23:49:59 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-01-13 戒馋,懒,贪

    谢谢分享学习了

    0

相关资讯

JAMA Psychiatry:新的研究发现,许多不同类型的焦虑和抑郁存在,你属于哪一种?

研究人员在斯坦福大学的一项研究中发现了五类新的精神疾病,这些类别涵盖了目前更广泛的焦虑和抑郁症的诊断。

Am J Psychiat:研究确定,焦虑增加是老年痴呆症的早期预警!

焦虑症在美国很普遍,每年大约有4000万成年人受到影响。然而,如果这些忧虑和恐惧的情绪不足以应付的话,很可能很危险。一项新的研究表明老年人焦虑症状的恶化可能更容易患上老年痴呆症。

Int J Geriatr Psychiatry:超过6年的抑郁和焦虑与视觉、听力和双重感官丧失之间的关系研究

最近,有研究人员在老年人中探究了双重和单独(视觉和听力)感官丧失与抑郁和焦虑症状之间的关系。研究包括了2890名年龄不小于60岁的老年人。主观视觉丧失、自我报道的听力损失或者双重感官丧失对抑郁和焦虑的影响通过贺普金斯症状检核表10来进行评估,并在时间基点和6年跟踪调查中利用了线性混合模型进行了分析。研究发现,听力损失与增加的抑郁(b = 0.1750, SE = 0.07, P = .02)和焦虑

J Behav Ther Exp Psychiatry:缺觉或睡太多,与焦虑和抑郁的关系

研究人员发现,睡眠不规律和重复性负面思维(RNT)之间存在着密切的联系。RNT的表现是经常陷入沉思和担忧。这是持续性认知的一种形式,这个涵盖性术语的意思是持续的、长期的沉思。这项研究发表在《行为疗法和实验精神病学期刊》上。

Neurology:老年帕金森患者临床焦虑评估的准确性研究

研究对帕金森患者的焦虑症状进行了评估,在研究考察的6种评估工具中,GAI表现出较好的应用效果,其敏感性和特异性较为平衡,而PAS虽然特异性较高,但敏感性较低。这一研究表明,在帕金森患者临床焦虑程度的评估过程中,不同的评估方法对结果影响较为显著

eLife:新发现或通向治疗焦虑和成瘾的新方法

一项发表在《eLife》上的新研究提供了关于大脑处理奖惩机制方式的新见解,为开发治疗从焦虑到药物滥用等成瘾行为的疾病开辟了新的途径。