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COVID-19继发的急性肺损伤：FDA批准RLS-0071进行临床试验

2020-07-29 Allan MedSci原创

急性肺损伤Covid-19RLS-0071
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制药公司ReAlta今天宣布，美国FDA已接受其RLS-0071的研究性新药（IND）申请，用于治疗COVID-19继发的急性肺损伤。

制药公司ReAlta今天宣布，美国FDA已接受其RLS-0071的研究性新药（IND）申请，用于治疗COVID-19继发的急性肺损伤。RLS-0071是一种工程化多肽，具有双重靶向机制，旨在通过直接与免疫细胞相互作用以调节其激活，同时可减少过度炎症来抑制补体和抗炎免疫反应。RLS-0071最初被开发用于治疗COVID-19相关的急性肺损伤和儿童缺氧缺血性脑病（HIE）。

在COVID-19患者中，病毒感染可导致不受控制的炎症和急性肺损伤。在临床前疾病模型中，RLS-0071具有调节补体、中性粒细胞和细胞因子激活并减少导致急性肺损伤的关键炎症途径的能力。

ReAlta首席执行官Ulrich Thienel博士表示：“COVID-19对患者的影响可能是极端的，包括威胁生命的肺部疾病。RLS-0071可能解决COVID-19继发的急性肺损伤等问题”。急性肺损伤是各种直接和间接致伤因素导致的肺泡上皮细胞及毛细血管内皮细胞损伤，造成弥漫性肺间质及肺泡水肿，导致的急性低氧性呼吸功能不全。

 

原始出处：

https://www.firstwordpharma.com/node/1744281?tsid=4

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    2021-05-27 bugit

    #FDA批准#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1839856, encodeId=c3d7183985624, content=<a href='/topic/show?id=341ae311ea' target=_blank style='color:#2F92EE;'>#FDA批准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7311, encryptionId=341ae311ea, topicName=FDA批准)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Thu May 27 14:16:52 CST 2021, time=2021-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1724522, encodeId=7f771e2452251, content=<a href='/topic/show?id=78ece8958b2' target=_blank style='color:#2F92EE;'>#继发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78958, encryptionId=78ece8958b2, topicName=继发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d33645837, createdName=feifers, createdTime=Thu Mar 11 11:16:52 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395407, encodeId=8b43139540e56, content=<a href='/topic/show?id=d051523897d' target=_blank style='color:#2F92EE;'>#急性肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52389, encryptionId=d051523897d, topicName=急性肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jul 31 01:16:52 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398019, encodeId=4e6a139801924, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Jul 31 01:16:52 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503332, encodeId=cfb115033329c, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05329610584, createdName=tastas, createdTime=Fri Jul 31 01:16:52 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805028, encodeId=3c0c80502875, content=这是急性肺损伤的福英, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5eef2099827, createdName=1801f6448em, createdTime=Wed Jul 29 10:25:26 CST 2020, time=2020-07-29, status=1, ipAttribution=)]
    2021-03-11 feifers

    #继发#

    0

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    2020-07-31 仁医06

    #急性肺损伤#

    0

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    2020-07-31 ms3046638856685384

    #损伤#

    0

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    2020-07-31 tastas

    #肺损伤#

    0

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    2020-07-29 1801f6448em

    这是急性肺损伤的福英

    0

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