JAHA:急性心力衰竭入院后新诊断感染的临床意义

2021-11-04 MedSci原创 MedSci原创

患有多种合并症的老年患者与因急性心力衰竭入院后新诊断的感染相关。急性心力衰竭患者入院后新诊断的感染与较高的院内和出院后死亡率相关。

感染是住院的常见诱发因素,并与心力衰竭患者的死亡率增加有关。此外,因失代偿性心衰入院的患者和并发感染的患者院内死亡率较高。然而,没有研究探讨急性心力衰竭患者入院后新诊断的感染与患者临床结局之间的关联。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在探讨与急性心力衰竭入院后新诊断感染相关的因素,及其与患者在院内和出院后临床结局之间的关系。

在京都充血性心力衰竭注册登记中心的4056名患者中,研究人员分析了入院时没有任何明显传染性疾病的2399名患者。该研究的主要院内和出院后结局指标为全因死亡。住院期间新发感染为215例(9.0%)患者,住院期间未发生感染性疾病的患者为2184例(91.0%)。

与新诊断感染独立相关的因素包括年龄80岁以上、急性冠脉综合征、无法行走、低钠血症、贫血、插管以及未使用袢利尿剂的门诊患者。与非感染组相比,新诊断的感染与较高的院内死亡率(16.3%和3.2%,P<0.001)和调整后院内死亡率过高风险相关(比值比为6.07[95%CI为3.61-10.19]),P<0.001)。与非感染组相比,新诊断感染组还与患者较高的1年出院后死亡率(新诊断感染组为19.3%,非感染组为13.6%,P<0.001)以及过高的出院死亡风险(风险比为1.49[95%CI为1.08-2.07],P=0.02)相关。

由此可见,患有多种合并症的老年患者与因急性心力衰竭入院后新诊断的感染相关。急性心力衰竭患者入院后新诊断的感染与较高的院内和出院后死亡率相关。

原始出处:

Yuta Seko.et al.Newly Diagnosed Infection After Admission for Acute Heart Failure: From the KCHF Registry.JAHA.2021.https://www.ahajournals.org/doi/10.1161/JAHA.121.023256

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    2022-02-01 rgjl
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    2021-11-06 zhaohui6731
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    2021-11-04 denglimoxiaoran

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    2021-11-04 ms9000000892709945

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