eLife:人类脑容量比预期大十倍,相当于整个互联网

2016-01-25 佚名 生物谷

图片来自:www.linkedin.com 如同计算机一样,我们的大脑储存记忆的能力令人印象深刻。科学家早就知道,大脑存储记忆的模式为在神经元间移动的电脉冲。但是科学家从来没有能够准确地量化,正常人的大脑到底能够存储多少信息。现在,索尔克研究所的研究人员,已经使用大鼠神经元模型,从而估计人类大脑的信息存储容量为1PB级别,新的估计值比以前的估计的信息量大了10倍。相关工作成果发表在eLife

图片来自:www.linkedin.com

如同计算机一样,我们的大脑储存记忆的能力令人印象深刻。科学家早就知道,大脑存储记忆的模式为在神经元间移动的电脉冲。但是科学家从来没有能够准确地量化,正常人的大脑到底能够存储多少信息。现在,索尔克研究所的研究人员,已经使用大鼠神经元模型,从而估计人类大脑的信息存储容量为1PB级别,新的估计值比以前的估计的信息量大了10倍。相关工作成果发表在eLife上。

研究人员知道,从一个神经元到下一个神经元的神经突触,是信息流动的主要空间,对大脑存储信息容量非常重要,同时对于其他大多数神经功能也是意义重大。但科学家还是不明白很多,在大脑中神经突触是如何工作的,包括它们的大小会如何影响信息的传输或存储。

在这项研究中,研究人员对在大鼠的海马进行非常精细的数字化重建。已知海马体是大脑中与长期记忆密切相关的区域,对于该区域的计算机建模可能帮助人们更好地理解记忆的工作方式。在最小的尺度上,研究人员惊奇地发现,神经元中的10%左右会有两个突触,来将它们连接到其他神经元上,而其余90%的神经元只有一个突触。虽然这些突触之间只有约8%的大小变化,研究人员发现在小鼠的整个海马中,有26种不同大小的突触。用计算机的术语来说,这意味着,每个突触可以存储平均4.7比特。在整个大脑中,这些突触总共的信息存储量可以达到惊人的1PB级别,即为1000TB,或者一百万GB的存储量。

但是1PB的这个数字也存在一些疑问。比如,虽然老鼠的大脑和人类大脑有着惊人的相似,但并不完全一样。且突触的规模、种类等,都会与物种类型有一定关联。不仅如此,突触的大小和数量,在不同的人群间,还存在着一定的个体差异。所以基于1PB的这个数据,有科学家估计人类的大脑信息存储极限可以到达3到5个PB级别。研究人员对大脑如何使用这个惊人的存储容量,还存在着很多的疑问。因为突触只有10%到20%的时间在传递数据,这使得数据的组织方式非常复杂。他们计划继续解释这些问题,这可能有助于计算机科学家找到更有效的方式,来组织计算机的超大存储空间,来促进计算机的深度学习等技术的发展。

原始出处:

Thomas M Bartol Jr, Cailey Bromer,et al,Nanoconnectomic upper bound on the variability of synaptic plasticity ,elife,2015Nanoconnectomic upper bound on the variability of synaptic plasticity.elife.2015

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    2016-05-14 仁医06
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    2016-10-11 clmlylxy
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    2016-01-27 李继凯

    开发吧

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1972954, encodeId=addd19e2954a4, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 14 17:14:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068452, encodeId=6911206845293, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Tue Oct 11 09:14:00 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60939, encodeId=4dd7609395f, content=开发吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 17:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60940, encodeId=4a90609400b, content=强大的人类, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 17:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60769, encodeId=349560e6970, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 12:52:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60590, encodeId=330060590b5, content=开发大脑, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 12:31:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274037, encodeId=801f12e4037c1, content=<a href='/topic/show?id=04fd241222d' target=_blank style='color:#2F92EE;'>#互联网#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24122, encryptionId=04fd241222d, topicName=互联网)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2726119, createdName=july_975, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575702, encodeId=600415e570263, content=<a href='/topic/show?id=d36784824fe' target=_blank style='color:#2F92EE;'>#脑容量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84824, encryptionId=d36784824fe, topicName=脑容量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65b816152155, createdName=aids218, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59579, encodeId=a38f595e982, content=上帝真牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 15:08:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59550, encodeId=35885955027, content=以后干这行, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=201b1682212, createdName=1de398e9m17(暂无匿称), createdTime=Tue Jan 26 14:58:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-27 李继凯

    强大的人类

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1972954, encodeId=addd19e2954a4, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 14 17:14:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068452, encodeId=6911206845293, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Tue Oct 11 09:14:00 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60939, encodeId=4dd7609395f, content=开发吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 17:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60940, encodeId=4a90609400b, content=强大的人类, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 17:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60769, encodeId=349560e6970, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 12:52:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60590, encodeId=330060590b5, content=开发大脑, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 12:31:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274037, encodeId=801f12e4037c1, content=<a href='/topic/show?id=04fd241222d' target=_blank style='color:#2F92EE;'>#互联网#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24122, encryptionId=04fd241222d, topicName=互联网)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2726119, createdName=july_975, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575702, encodeId=600415e570263, content=<a href='/topic/show?id=d36784824fe' target=_blank style='color:#2F92EE;'>#脑容量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84824, encryptionId=d36784824fe, topicName=脑容量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65b816152155, createdName=aids218, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59579, encodeId=a38f595e982, content=上帝真牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 15:08:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59550, encodeId=35885955027, content=以后干这行, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=201b1682212, createdName=1de398e9m17(暂无匿称), createdTime=Tue Jan 26 14:58:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-27 李继凯

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1972954, encodeId=addd19e2954a4, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 14 17:14:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068452, encodeId=6911206845293, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Tue Oct 11 09:14:00 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60939, encodeId=4dd7609395f, content=开发吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 17:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60940, encodeId=4a90609400b, content=强大的人类, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 17:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60769, encodeId=349560e6970, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 12:52:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60590, encodeId=330060590b5, content=开发大脑, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 12:31:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274037, encodeId=801f12e4037c1, content=<a href='/topic/show?id=04fd241222d' target=_blank style='color:#2F92EE;'>#互联网#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24122, encryptionId=04fd241222d, topicName=互联网)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2726119, createdName=july_975, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575702, encodeId=600415e570263, content=<a href='/topic/show?id=d36784824fe' target=_blank style='color:#2F92EE;'>#脑容量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84824, encryptionId=d36784824fe, topicName=脑容量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65b816152155, createdName=aids218, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59579, encodeId=a38f595e982, content=上帝真牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 15:08:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59550, encodeId=35885955027, content=以后干这行, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=201b1682212, createdName=1de398e9m17(暂无匿称), createdTime=Tue Jan 26 14:58:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-27 文医生

    开发大脑

    0

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  8. [GetPortalCommentsPageByObjectIdResponse(id=1972954, encodeId=addd19e2954a4, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 14 17:14:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068452, encodeId=6911206845293, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Tue Oct 11 09:14:00 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60939, encodeId=4dd7609395f, content=开发吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 17:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60940, encodeId=4a90609400b, content=强大的人类, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 17:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60769, encodeId=349560e6970, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 12:52:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60590, encodeId=330060590b5, content=开发大脑, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 12:31:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274037, encodeId=801f12e4037c1, content=<a href='/topic/show?id=04fd241222d' target=_blank style='color:#2F92EE;'>#互联网#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24122, encryptionId=04fd241222d, topicName=互联网)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2726119, createdName=july_975, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575702, encodeId=600415e570263, content=<a href='/topic/show?id=d36784824fe' target=_blank style='color:#2F92EE;'>#脑容量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84824, encryptionId=d36784824fe, topicName=脑容量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65b816152155, createdName=aids218, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59579, encodeId=a38f595e982, content=上帝真牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 15:08:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59550, encodeId=35885955027, content=以后干这行, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=201b1682212, createdName=1de398e9m17(暂无匿称), createdTime=Tue Jan 26 14:58:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-27 aids218
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    2016-01-26 doctording1

    上帝真牛

    0

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    2016-01-26 1de398e9m17(暂无匿称)

    以后干这行

    0

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