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Engineering tumor constructs to study matrix-dependent angiogenic signaling of breast cancer cells

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (3)

Breast cancer is the leading cause of cancer deaths among females globally. The crosstalk between tumor microenvironment and neoplastic cells is the k......

JIF:2.455

Efficient immobilized phospholipase A1 on Mo-basing nanomaterials for enzymatic degumming

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (4)

Six kinds of Mo-basing nanomaterials (MoO3, MoO3@Ru, Mo-PDA, MoP(R), MoP, CNT@MoS2) were successfully synthesized, which were employed as carriers to ......

JIF:2.455

Impact of different trace elements on metabolic routes during heterotrophic growth of C. ljungdahlii investigated through online measurement of the carbon dioxide transfer rate

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (4)

Synthesis gas fermentation using acetogenic clostridia is a rapidly increasing research area. It offers the possibility to produce platform chemicals ......

JIF:2.455

Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (2)

Virus removal filtration is a critical step in the manufacture of monoclonal antibody products, providing a robust size-based removal of both envelope......

JIF:2.455

Changes to culture pH and dissolved oxygen can enhance chimeric antigen receptor T-cell generation and differentiation

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (5)

Chimeric antigen receptor (CAR) T-cell therapy is growing clinically and commercially as a powerful new approach to treat cancer. Understanding how ke......

JIF:2.455

Bax and Bak knockout apoptosis-resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed-batch culture process

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (2)

In the field of therapeutic protein production, process intensification strategies entailing higher starting cell seeding densities, can potentially i......

JIF:2.455

Antibody glycation during a Chinese hamster ovary fed-batch process is following a constrained second order reaction

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (5)

Glycation on lysine side chains of recombinant monoclonal antibodies (mAb) is a well-known phenomenon in manufacturing processes of biopharmaceuticals......

JIF:2.455

Streamlined process development procedure incorporating the selection of various stationary phase types established in a mAb aggregate reduction study with different mixed mode ligands

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (2)

In biopharmaceutical process development time, cost and reliability are the relevant keywords. During the development of chromatographic processes the......

JIF:2.455

Copper impurity of iron raw material contributes to improved cell culture performance

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (4)

Cell culture medium (CCM) formulations are chemically defined to reduce lot-to-lot variability and complexity of the medium while still providing all ......

JIF:2.455

Rapid intensification of an established CHO cell fed-batch process

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (1)

Currently, the mammalian biomanufacturing industry explores process intensification (PI) to meet upcoming demands of biotherapeutics while keeping pro......

JIF:2.455

Identification of compendial nonionic detergents for the replacement of Triton X-100 in bioprocessing

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (2)

We have systematically investigated six compendial nonionic detergents as potential replacements for Triton x-100 in bioprocessing applications. Use o......

JIF:2.455

Generation of a host cell line containing a MAR-rich landing pad for site-specific integration and expression of transgenes

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (4)

In recent years, targeted gene integration (TI) has been introduced as a strategy for the generation of recombinant mammalian cell lines for the produ......

JIF:2.455

Modification of C-segment of Cfa DnaE split intein for improving clean-in-place in chromatography process

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (5)

This research focuses on the construction of an affinity purification system based on Cfa DnaE split intein. Cfa DnaE intein is an artificially constr......

JIF:2.455

The impact of temozolomide and lonafarnib on the stemness marker expression of glioblastoma cells in multicellular spheroids

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (5)

Glioblastoma multiforme (GBM) is a highly malignant brain tumor with a poor prognosis. The GBM microenvironment is highly heterogeneous and is compose......

JIF:2.455

A systematic approach to reduce intraocular pressure for the treatment of glaucoma

期刊: BIOTECHNOLOGY PROGRESS, 2022; 38 (6)

Glaucoma is the leading cause of irreversible blindness due to increased intraocular pressure (IOP) in the eye. We have developed a novel treatment op......

JIF:2.455

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