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Combretastatin A1联合阿糖胞苷治疗复发性急性髓细胞白血病成人患者中取得积极结果

2019-12-24 Allan MedSci原创

急性髓细胞白血病CombretastatinA1阿糖胞苷
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Mateon Therapeutics近日宣布，Combretastatin A1（OXi4503）联合阿糖胞苷治疗复发性急性髓细胞白血病（AML）达到了其主要终点。研究表明，在26例可评估的AML患者中，有4例完全缓解（CR / CRi）和1例部分缓解（PR）。

Mateon Therapeutics近日宣布，Combretastatin A1（OXi4503）联合阿糖胞苷治疗复发性急性髓细胞白血病（AML）达到了其主要终点。研究表明，在26例可评估的AML患者中，有4例完全缓解（CR / CRi）和1例部分缓解（PR）。CR反应与>1年的总生存时间相关。对于患有复发性AML的老年人，联合治疗显示出可控的毒性和对风险状况的潜在益处。

这项新疗法在复发难治AML中的安全性、可行性和早期临床活性值得在随机研究中进一步进行验证。该研究的结果将在即将举行的医学会议上发表，并与包括美国FDA在内的卫生当局进行讨论。


原始出处：

http://www.firstwordpharma.com/node/1689680#axzz68z4pBXnX

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    2022-04-26 病毒猎手

    #急性髓细胞白血病##阿糖胞苷#

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    2022-04-26 病毒猎手

    #急性髓细胞白血病#

    0

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    2020-07-15 ysjykql

    #RET#

    0

  4. 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style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-02-15 DEXTER3139

    #Stati#

    0

  5. 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style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-04-20 shenxlcyp

    #髓细胞白血病#

    0

  6. 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topicList=[TopicDto(id=16762, encryptionId=a56b16e6260, topicName=Statin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 08 07:38:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712243, encodeId=91611e1224392, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Jul 21 09:38:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783536, encodeId=9ced1e8353646, content=<a href='/topic/show?id=e67d501343' target=_blank style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-05-17 hb2008ye

    #复发性#

    0

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createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Mon Apr 20 18:38:00 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909798, encodeId=fec51909e9891, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun May 17 09:38:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068897, encodeId=2a77206889e2a, content=<a href='/topic/show?id=a56b16e6260' target=_blank style='color:#2F92EE;'>#Statin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16762, encryptionId=a56b16e6260, topicName=Statin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 08 07:38:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712243, encodeId=91611e1224392, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Jul 21 09:38:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783536, encodeId=9ced1e8353646, content=<a href='/topic/show?id=e67d501343' target=_blank style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-01-08 snowpeakxu

    #Statin#

    0

  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794310, encodeId=3b491e9431052, content=<a href='/topic/show?id=04b316e617e' target=_blank style='color:#2F92EE;'>#Stati#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16761, encryptionId=04b316e617e, topicName=Stati)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Sat Feb 15 11:38:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822175, encodeId=c6a318221e56f, content=<a href='/topic/show?id=b8611021308a' target=_blank style='color:#2F92EE;'>#髓细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102130, encryptionId=b8611021308a, topicName=髓细胞白血病)], attachment=null, authenticateStatus=null, 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topicList=[TopicDto(id=16762, encryptionId=a56b16e6260, topicName=Statin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 08 07:38:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712243, encodeId=91611e1224392, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Jul 21 09:38:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783536, encodeId=9ced1e8353646, content=<a href='/topic/show?id=e67d501343' target=_blank style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-07-21 ms24272190615788285182

    #AST#

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794310, encodeId=3b491e9431052, content=<a href='/topic/show?id=04b316e617e' target=_blank style='color:#2F92EE;'>#Stati#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16761, encryptionId=04b316e617e, topicName=Stati)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Sat Feb 15 11:38:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822175, encodeId=c6a318221e56f, content=<a href='/topic/show?id=b8611021308a' target=_blank style='color:#2F92EE;'>#髓细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102130, encryptionId=b8611021308a, topicName=髓细胞白血病)], attachment=null, authenticateStatus=null, 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topicList=[TopicDto(id=16762, encryptionId=a56b16e6260, topicName=Statin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 08 07:38:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712243, encodeId=91611e1224392, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Jul 21 09:38:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783536, encodeId=9ced1e8353646, content=<a href='/topic/show?id=e67d501343' target=_blank style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-03-14 lilianxiang

    #Combretastatin#

    0

  10. 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    2019-12-26 chengjn

    #髓细胞#

    0

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